About: Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination

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About: Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination
Creator	Pablo, Jozelyn Adams, Matthew Doumbo, Ogobara Lyke, Kirsten Nakajima, Rie Patel, Jigar Tan, John Laurens, Matthew Bailey, Jason Bannen, Ryan Berry, Andrea Boudova, Sarah Coulibaly, Drissa Dotsey, Emmanuel Dutta, Sheetij Felgner, L Jacob, G Jasinskas, Algis Kouriba, Bourema Niangaly, Amadou Ouattara, Amed Pike, Andrew Plowe, V Takala-Harrison, Shannon Thera, Mahamadou Travassos, Mark
Source	PMC
abstract	Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses to malaria infection and AMA1 vaccination, we designed protein and peptide microarrays representing hundreds of unique AMA1 variants. Following clinical malaria episodes, children had short-lived, sequence-independent increases in average whole-protein seroreactivity, as well as strain-specific responses to peptides representing diverse epitopes. Vaccination resulted in dramatically increased seroreactivity to all 263 AMA1 whole-protein variants. High-density peptide analysis revealed that vaccinated children had increases in seroreactivity to four distinct epitopes that exceeded responses to natural infection. A single amino acid change was critical to seroreactivity to peptides in a region of AMA1 associated with strain-specific vaccine efficacy. Antibody measurements using whole antigens may be biased towards conserved, immunodominant epitopes. Peptide microarrays may help to identify immunogenic epitopes, define correlates of vaccine protection, and measure strain-specific vaccine-induced antibodies.
has issue date	2020-03-03(xsd:dateTime)
bibo:doi	10.1038/s41598-020-60551-z
bibo:pmid	32127565
has license	cc-by
sha1sum (hex)	09202b5dcb04f88711ac3757998c296603a65ae9
schema:url	https://doi.org/10.1038/s41598-020-60551-z
resource representing a document's title	Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination
has PubMed Central identifier	PMC7054363
has PubMed identifier	32127565
schema:publication	Sci Rep
resource representing a document's body	covid:09202b5dcb04f88711ac3757998c296603a65ae9#body_text
is schema:about of	named entity 'critical' named entity 'apical membrane' named entity 'Peptide' named entity 'Antibody' named entity 'infection' named entity 'HAVE' named entity 'VACCINATED' named entity 'APICAL MEMBRANE ANTIGEN 1' named entity 'HELP' named entity 'IMMUNOGENIC' named entity 'conserved' named entity 'peptides' named entity 'efficacy' named entity 'protein' named entity 'based' named entity 'antibodies' named entity 'natural' named entity 'Vaccination' named entity 'microarrays' named entity 'epitopes' named entity 'malaria' named entity 'polymorphism' named entity 'epitopes' named entity 'apical membrane antigen' named entity 'epitopes' named entity 'antibodies' named entity 'antibody' named entity 'parasites' named entity 'homologous' named entity 'protein array' named entity 'peptide' named entity 'peptide' named entity 'control groups' named entity 'antibody' named entity 'Antibodies' named entity 'infection' named entity 'peptides' named entity 'protein' named entity 'epitopes' named entity 'antibodies' named entity 'peptides' named entity 'hypervariable' named entity 'E. coli' named entity 'non-human primates' named entity 'protein array' named entity 'peptides' named entity 'antigenic variation' named entity 'malaria transmission' named entity 'haplotype' named entity 'peptide' named entity 'serotype' named entity 'nature.com' named entity 'plasmid vector' named entity 'University of Maryland, Baltimore' named entity 'amino acid' named entity 'malaria transmission'

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