About: Identification of an epitope of SARS-coronavirus nucleocapsid protein

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About: Identification of an epitope of SARS-coronavirus nucleocapsid protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of an epitope of SARS-coronavirus nucleocapsid protein
Creator	Li, Yi Wang, Yuan Wang, Jin Sun, Bing Lu, Wei Wang, Hong Lin, Ying Jiang, Hua Ji, Yong Xie, You De Shi, M Fen Shen, Bei Fu Yang, Rui Gang, Pei He, You Hua Shen, Jian Rui Wu, Jia Shi, Tie Shen, X
Source	Medline; PMC
abstract	The nucleocapsid (N) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) is a major virion structural protein. In this study, two epitopes (N1 and N2) of the N protein of SARS-CoV were predicted by bioinformatics analysis. After immunization with two peptides, the peptides-specific antibodies were isolated from the immunized rabbits. The further experiments demonstrated that N1 peptide-induced polyclonal antibodies had a high affinity to bind to E. coli expressed N protein of SARS-CoV. Furthermore, it was confirmed that N1 peptide-specific IgG antibodies were detectable in the sera of severe acute respiratory syndrome (SARS) patients. The results indicated that an epitope of the N protein has been identified and N protein specific Abs were produced by peptide immunization, which will be useful for the study of SARS-CoV.
has issue date	2003-06-01(xsd:dateTime)
bibo:doi	10.1038/sj.cr.7290158
bibo:pmid	12862314
has license	no-cc
sha1sum (hex)	09231c006e8603fe345d309934c0f81fd2e51398
schema:url	https://doi.org/10.1038/sj.cr.7290158
resource representing a document's title	Identification of an epitope of SARS-coronavirus nucleocapsid protein
has PubMed Central identifier	PMC7091728
has PubMed identifier	12862314
schema:publication	Cell Res
resource representing a document's body	covid:09231c006e8603fe345d309934c0f81fd2e51398#body_text
is schema:about of	named entity 'nucleocapsid' named entity 'specific' named entity 'epitope' named entity 'NUCLEOCAPSID' named entity 'IMMUNIZATION' named entity 'PREDICTED' named entity 'SARS-COV' named entity 'PEPTIDE' named entity 'IS A' named entity 'AFFINITY' named entity 'DETECTABLE' named entity 'E. COLI' named entity 'INDICATED' named entity 'A MAJOR' named entity 'CORONAVIRUS' named entity 'SARS' named entity 'IDENTIFICATION' covid:arg/09231c006e8603fe345d309934c0f81fd2e51398 named entity 'VIRION' named entity 'NUCLEOCAPSID' named entity 'EPITOPE' named entity 'PRO-' named entity 'USEFUL' named entity 'POLYCLONAL ANTIBODIES' named entity 'EPITOPES' named entity 'EPITOPE' named entity 'RABBITS' named entity 'SPECIFIC' named entity 'RESULTS' named entity 'TO BIND TO' named entity 'ANTIBODIES' named entity 'ABS' named entity 'IDENTIFIED' named entity 'BIOINFORMATICS ANALYSIS' named entity 'STUDY' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'CORONAVIRUS' named entity 'CONFIRMED' named entity 'N PROTEIN' named entity 'PATIENTS' named entity 'IMMUNIZED' named entity 'ISOLATED' named entity 'PROTEIN ' named entity 'IGG' named entity 'DEMONSTRATED' named entity 'EXPERIMENTS' named entity 'PEPTIDES' named entity 'HIGH' named entity 'STRUCTURAL PROTEIN' named entity 'EXPRESSED' named entity 'SERA' named entity 'virion' named entity 'protein' named entity 'immunized' named entity 'protein' named entity 'protein' named entity 'confirmed' named entity 'SARS-CoV' named entity 'E. coli' named entity 'respiratory' named entity 'structural protein' named entity 'protein' named entity 'high affinity'

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