About: Autophagy: More Than a Nonselective Pathway

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autophagy: More Than a Nonselective Pathway
Creator	Reggiori, Fulvio Komatsu, Masaaki Simonsen, Anne Finley, Kim
Source	PMC
abstract	Autophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly eliminate large unwanted structures such as aberrant protein aggregates, superfluous or damaged organelles, and invading pathogens. The hallmark of this transport pathway is the sequestration of the cargoes that have to be degraded in the lysosomes by double-membrane vesicles called autophagosomes. The key actors mediating the biogenesis of these carriers are the autophagy-related genes (ATGs). For a long time, it was assumed that autophagy is a bulk process. Recent studies, however, have highlighted the capacity of this pathway to exclusively eliminate specific structures and thus better fulfil the catabolic necessities of the cell. We are just starting to unveil the regulation and mechanism of these selective types of autophagy, but what it is already clearly emerging is that structures targeted to destruction are accurately enwrapped by autophagosomes through the action of specific receptors and adaptors. In this paper, we will briefly discuss the impact that the selective types of autophagy have had on our understanding of autophagy.
has issue date	2012-05-15(xsd:dateTime)
bibo:doi	10.1155/2012/219625
bibo:pmid	22666256
has license	cc-by
sha1sum (hex)	09340528717039c904847d959dd4ff0adcc308ed
schema:url	https://doi.org/10.1155/2012/219625
resource representing a document's title	Autophagy: More Than a Nonselective Pathway
has PubMed Central identifier	PMC3362037
has PubMed identifier	22666256
schema:publication	Int J Cell Biol
resource representing a document's body	covid:09340528717039c904847d959dd4ff0adcc308ed#body_text
is schema:about of	named entity 'PAPER' named entity 'DISCUSS' named entity 'DAMAGED' named entity 'OUR' named entity 'RAPIDLY' named entity 'PATHWAY' named entity 'PATHOGENS' named entity 'ACTION' named entity 'RECENT' named entity 'EUKARYOTES' named entity 'WHAT' named entity 'CONSERVED' named entity 'BETTER' named entity 'AUTOPHAGY' named entity 'specific' named entity 'sequestration' named entity 'aberrant' named entity 'lysosomes' named entity 'structures' named entity 'biogenesis' named entity 'cell' named entity 'DEGRADED' named entity 'ORGANELLES' named entity 'DESTRUCTION' named entity 'ASSUMED' named entity 'JUST' named entity 'AUTOPHAGY-RELATED GENES' named entity 'AUTOPHAGY' named entity 'ALLOWS' named entity 'MEDIATING' named entity 'STUDIES' named entity 'SELECTIVE' named entity 'TARGETED' named entity 'ABERRANT PROTEIN' named entity 'PROCESS' named entity 'AUTOPHAGOSOMES' named entity 'CELLS' named entity 'BIOGENESIS' named entity 'TRANSPORT PATHWAY' named entity 'CAPACITY' named entity 'STARTING' named entity 'THESE' named entity 'LARGE' named entity 'ACTORS' named entity 'IMPACT' named entity 'TYPES' named entity 'PROTEIN AGGREGATES' named entity 'HAVE' named entity 'CATABOLIC' named entity 'CATABOLIC PATHWAY' named entity 'BUT' named entity 'BULK' named entity 'IS A' named entity 'PATHWAY' named entity 'MORE THAN' named entity 'SEQUESTRATION' named entity 'LYSOSOMES' named entity 'KEY' named entity 'TIME' named entity 'UNDERSTANDING' named entity 'CARRIERS' named entity 'MEMBRANE' named entity 'REGULATION' named entity 'STRUCTURES' named entity 'MECHANISM' named entity 'RECEPTORS' named entity 'LONG' named entity 'DOUBLE' named entity 'VESICLES' named entity 'SPECIFIC' named entity 'protein' named entity 'action' named entity 'hallmark' named entity 'time' named entity 'accurately' named entity 'transport' named entity 'adaptors' named entity 'mediating'

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