About: HIV-Specific T-Cells Accumulate in the Liver in HCV/HIV Co-Infection

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About: HIV-Specific T-Cells Accumulate in the Liver in HCV/HIV Co-Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	HIV-Specific T-Cells Accumulate in the Liver in HCV/HIV Co-Infection
Creator	Loutfy, Mona Common, Andrew Halpenny, Roberta Kaul, Rupert Kovacs, Colin Vali, Bahareh Wong, David Betts, Michael Jones, R Ostrowski, Mario Sheth, Prameet Yue, Yun
topic	covid:0951f5ec3710990a5c181e04fa8fdf7d9a0376e5#this
Source	PMC
abstract	BACKGROUND AND AIMS: Hepatitis C Virus (HCV)-related liver disease progresses more rapidly in individuals co-infected with Human Immunodeficiency Virus-1 (HIV), although the underlying immunologic mechanisms are unknown. We examined whether HIV-specific T-cells are identified in the liver of HCV/HIV co-infected individuals and promote liver inflammation through bystander immune responses. METHODS: Ex-vivo intra-hepatic lymphocytes from HCV mono-infected and HCV/HIV co-infected individuals were assessed for immune responses to HIV and HCV antigens by polychromatic flow cytometry. RESULTS: HCV/HIV liver biopsies had similar frequencies of lymphocytes but lower percentages of CD4(+) T-cells compared to HCV biopsies. In co-infection, intra-hepatic HIV-specific CD8(+) and CD4(+) T-cells producing IFN-γ and TNF-α were detected and were comparable in frequency to those that were HCV-specific. In co-infected individuals, viral-specific CD8(+) T-cells produced more of the fibrogenic cytokine, TNF-α. In both mono- and co-infected individuals, intra-hepatic HCV-specific T-cells were poorly functional compared to HIV-specific T-cells. In co-infection, HAART was not associated with a reconstitution of intra-hepatic CD4(+) T-cells and was associated with reduction in both HIV and HCV-specific intra-hepatic cytokine responses. CONCLUSION: The accumulation of functional HIV-specific T-cells in the liver during HCV/HIV co-infection may represent a bystander role for HIV in inducing faster progression of liver disease.
has issue date	2008-10-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0003454
bibo:pmid	18941622
has license	cc-by
sha1sum (hex)	0951f5ec3710990a5c181e04fa8fdf7d9a0376e5
schema:url	https://doi.org/10.1371/journal.pone.0003454
resource representing a document's title	HIV-Specific T-Cells Accumulate in the Liver in HCV/HIV Co-Infection
has PubMed Central identifier	PMC2565067
has PubMed identifier	18941622
schema:publication	PLoS One
resource representing a document's body	covid:0951f5ec3710990a5c181e04fa8fdf7d9a0376e5#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/0951f5ec3710990a5c181e04fa8fdf7d9a0376e5
is schema:about of	named entity 'INDIVIDUALS' named entity 'UNDERLYING' named entity 'AIMS' named entity 'EXAMINED' named entity 'MECHANISMS' named entity 'RAPIDLY' named entity 'PROGRESSES' named entity 'T-CELLS' named entity 'HCV' named entity 'liver inflammation' named entity 'HIV' named entity 'T-CELLS' named entity 'SPECIFIC' named entity 'RELATED' named entity 'HCV' named entity 'IMMUNE RESPONSES' named entity 'LIVER DISEASE' named entity 'HIV' named entity 'IDENTIFIED' named entity 'INFECTED' named entity 'LIVER INFLAMMATION' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'BACKGROUND' named entity 'HIV' covid:arg/0951f5ec3710990a5c181e04fa8fdf7d9a0376e5 named entity 'CO-INFECTION' named entity 'BYSTANDER' named entity 'SPECIFIC' named entity 'UNKNOWN' named entity 'LIVER' named entity 'PROMOTE' named entity 'IMMUNOLOGIC' named entity 'HEPATITIS C VIRUS' named entity 'LIVER' named entity 'HIV' named entity 'Human Immunodeficiency Virus-1' named entity 'HCV' named entity 'liver' named entity 'HIV' named entity 'Liver' named entity 'HCV' named entity 'HIV' named entity 'HIV' named entity 'Liver' named entity 'HAART' named entity 'HAART' named entity 'HIV' named entity 'hepatotropic viruses' named entity 'virus' named entity 'HIV-1' named entity 'T-cells' named entity 'EBV' named entity 'HCV' named entity 'liver disease' named entity 'CD8' named entity 'HCV' named entity 'liver' named entity 'staining' named entity 'infection' named entity 'CMV' named entity 'co-infection' named entity 'NS3' named entity 'T-cells' named entity 'liver disease' named entity 'liver fibrosis' named entity 'T-cell' named entity 'lymphocytes' named entity 'T-cells'

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