About: Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

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About: Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
Creator	Hamano, Emi Hijikata, Minako Keicho, Naoto Matsushita, Ikumi Itoyama, Satoru Kirikae, Teruo Kuratsuji, Tadatoshi Quy, Tran Sasazuki, Takehiko Yanai, Hideki Kirikae, Fumiko Dang Ha, Le Long, Hoang Phi, Nguyen Van Ban, Vo
Source	Elsevier; Medline; PMC
abstract	Abstract We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2′,5′-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p =0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position −88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p =0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.
has issue date	2005-04-22(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2005.02.101
bibo:pmid	15766558
has license	els-covid
sha1sum (hex)	09e8ffe2b970364e969a4b167ed6ecd1ff8f9554
schema:url	https://doi.org/10.1016/j.bbrc.2005.02.101
resource representing a document's title	Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
has PubMed Central identifier	PMC7092916
has PubMed identifier	15766558
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:09e8ffe2b970364e969a4b167ed6ecd1ff8f9554#body_text
is schema:about of	named entity 'POPULATION' named entity 'level' named entity 'patients' named entity 'susceptibility' named entity 'induced' named entity 'OAS' named entity 'SARS' named entity 'POLYMORPHISMS' named entity 'PATIENTS' named entity 'SUSCEPTIBILITY' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'NON-' named entity 'INFECTION' named entity 'TYPE I INTERFERONS' named entity 'FINDINGS' named entity 'POSITION' named entity 'ANALYZED' named entity 'POLYMORPHISMS' named entity 'GENES' named entity '28P' named entity '103' named entity 'SARS' named entity 'STRONG' named entity 'INDUCED' named entity 'ASSOCIATION' named entity 'AFFECT' named entity 'INTERFERON' named entity 'OAS' named entity 'VIETNAMESE' named entity 'INDUCIBLE' named entity 'ASSOCIATED WITH' named entity 'GENE' named entity 'SYNONYMOUS' named entity 'NATURAL COURSE' named entity 'SUGGEST' named entity 'RESISTANCE' named entity 'MXA' named entity 'ALLELE' named entity 'FOUND' named entity 'GROUP' named entity 'GENE PROMOTER' named entity 'DISEASE' named entity 'SYNTHETASE' named entity 'LEVEL' named entity 'MXA' named entity 'MYXOVIRUS' named entity 'VIETNAMESE' named entity 'PROTEIN KINASE' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'LINKAGE DISEQUILIBRIUM' named entity 'OLIGOADENYLATE' named entity '2C5' named entity 'FREQUENTLY' named entity 'IFN' named entity 'OAS' named entity 'HOST' named entity 'OUR' named entity 'ASSOCIATED WITH' named entity 'GENOTYPE' named entity 'PROGRESSION' named entity 'GENES' named entity 'SNP' named entity 'DEPENDENT' named entity 'EXON' named entity 'ANTIVIRAL' named entity 'DOUBLE-STRANDED RNA' covid:arg/09e8ffe2b970364e969a4b167ed6ecd1ff8f9554

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