About: Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study

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About: Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study
Creator	Binjawadagi, Basavaraj Dhakal, Santosh Hiremath, Jagadish Ouyang, Kang Shyu, Duan-Liang Arcos, Jesus Holman, Lynette Roof, Michael Schleappi, Rose Renukaradhya, Gourapura Torrelles, Jordi
topic	covid:09f23fe560ba923e5960707d0b4451df85253b36#this
Source	Medline; PMC
abstract	Porcine reproductive and respiratory syndrome (PRRS) is caused by PRRS virus (PRRSV), which infects primarily the respiratory tract of pigs. Thus intranasal (IN) delivery of a potent vaccine-adjuvant formulation is promising. In this study, PRRS-MLV (VR2332) was coadministered ± an adjuvant Mycobacterium vaccae whole cell lysate or CpG ODN through intramuscular (IM) or IN route as a mist, and challenged with a heterologous PRRSV 1-4-4 IN at 42 days post-vaccination (dpv). At 14 and 26 dpv, vaccine viral RNA copies were one log greater in the plasma of PRRS-MLV IM compared to IN vaccinated pigs, and the infectious replicating vaccine virus was detected only in the IM group. In PRRS-MLV ± adjuvant IM vaccinated pigs, reduced viral RNA load and absence of the replicating challenged virus was observed at 7, 10 and 14 days post-challenge (dpc). At 14 dpc, in BAL fluid ≥5 log viral RNA copies were detected in all the pig groups, but the replicating challenged virus was undetectable only in IM groups. Immunologically, virus neutralizing antibody titers in the plasma of IM (but not IN) vaccine groups was ≥8 against the vaccine and challenged viruses. At 26 dpv, PRRS-MLV IM (without adjuvant) received pigs had significantly increased population of CD4 and CD8 T cells in PBMC. At 14 dpc, relatively increased population of IFN-γ(+) total lymphocytes, NK, CD4, CD8 and γδ T cells were observed in the MLV-IM group. In conclusion, PRRS-MLV IM vaccination induced the virus specific T cell response in pigs, but still it is required to improve its cross-protective efficacy.
has issue date	2016-03-17(xsd:dateTime)
bibo:doi	10.1186/s13567-016-0331-3
bibo:pmid	26988085
has license	cc-by
sha1sum (hex)	09f23fe560ba923e5960707d0b4451df85253b36
schema:url	https://doi.org/10.1186/s13567-016-0331-3
resource representing a document's title	Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study
has PubMed Central identifier	PMC4797253
has PubMed identifier	26988085
schema:publication	Vet Res
resource representing a document's body	covid:09f23fe560ba923e5960707d0b4451df85253b36#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/09f23fe560ba923e5960707d0b4451df85253b36
is schema:about of	named entity 'INFECTS' named entity 'UNDETECTABLE' named entity 'ABSENCE OF' named entity 'PUBLIC DOMAIN' named entity 'LINK' named entity 'COPIES' named entity 'CONCLUSION' named entity 'INTRAMUSCULAR' named entity 'EFFICACY' named entity 'INDUCED' named entity 'POST' named entity 'SOURCE' named entity 'REQUIRED' named entity 'FORMULATION' named entity 'CREATIVE COMMONS' named entity 'DPV' named entity 'DISTRIBUTED' named entity 'INFECTIOUS' named entity 'HETEROLOGOUS' named entity 'TERMS' named entity 'BUT' named entity 'PLASMA' named entity 'DPC' named entity 'CELL LYSATE' named entity 'USE' named entity 'INTRANASAL' named entity 'PBMC' named entity 'VIRAL RNA' named entity 'T CELLS' named entity 'ORG' named entity 'Public Domain' named entity 'distribution' named entity 'lymphocytes' named entity 'copies' named entity 'PRRS' named entity 'replicating' named entity 'observed' named entity 'immunization' named entity 'VIRUS' named entity 'IMMUNIZATION' named entity 'ROUTES' named entity 'LIVE' named entity 'GROUP' named entity '28S' named entity 'ANTIBODY TITERS' named entity 'PROVIDED' named entity 'FLUID' named entity 'REPRODUCTION' named entity 'RESPIRATORY TRACT' named entity 'CROSS' named entity 'UNRESTRICTED' named entity 'DETECTED' named entity 'CHALLENGE' named entity 'VIRUSES' named entity 'TOTAL' named entity 'ARTICLE' named entity 'PIG' named entity 'REDUCED' named entity 'WAIVER' named entity 'GROUPS' named entity 'STUDY' named entity 'ROUTE' named entity 'IFN' named entity 'VACCINATION' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME' named entity 'COMPARATIVE ANALYSIS' named entity 'CHALLENGE STUDY' named entity 'HETEROLOGOUS' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS'

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