About: Elevated RDW is Associated with Increased Mortality Risk in COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Elevated RDW is Associated with Increased Mortality Risk in COVID-19
Creator	Aguirre, Aaron Brandon Westover, M Carlson, Jonathan Contact, John Foy, Brody Higgins, Higgins, John Mow, Christopher Palanques-Tost, Eric Pallares Lopez, Roger Reinertsen, Erik Valls, Raimon
source	MedRxiv
abstract	Abstract Background Coronavirus disease 2019 (COVID19) is an acute respiratory illness with a high rate of hospitalization and mortality. Prognostic biomarkers are urgently needed. Red blood cell distribution width (RDW), a component of complete blood counts that reflects cellular volume variation, has been shown to be associated with elevated risk for morbidity and mortality in a wide range of diseases. Methods We retrospectively studied the relationship between RDW and COVID19 mortality risk for 1198 adult patients diagnosed with SARS COV2 at 4 Partners Healthcare Network Hospitals between March 4, 2020, and April 28, 2020. Findings Elevated RDW (> 14.5%) was associated with increased mortality in patients of all ages with a risk ratio of 2.5 (95% CI, 2.3-2.8). Stratified by age, the risk ratio was 6.2 (4.4-7.9, N = 312) < 50 years, 3.2 (2.5-4.1, N = 230) 50-60, 2.3 (1.6-3.1, N = 236) 60-70, 1.2 (0.7-1.8, N = 203) 70-80, and 1.9 (1.5-2.3, N = 216) > 80 years. RDW was significantly associated with mortality in Cox proportional hazards models adjusted for age, D-Dimer, absolute lymphocyte count, and common comorbidities (p < 1e-4 for RDW in all cases). Patients whose RDW increased during admission had a ~3-fold elevation in mortality risk compared to those whose RDW did not change. Interpretation Elevated RDW at diagnosis and an increase in RDW during admission are both associated with increased mortality risk for adult COVID19 patients at a large academic medical center network.
has issue date	2020-05-09(xsd:dateTime)
bibo:doi	10.1101/2020.05.05.20091702
has license	medrxiv
sha1sum (hex)	09f31dd2ecb80bc5beed4b6df618e45bb593ae42
schema:url	https://doi.org/10.1101/2020.05.05.20091702
resource representing a document's title	Elevated RDW is Associated with Increased Mortality Risk in COVID-19
resource representing a document's body	covid:09f31dd2ecb80bc5beed4b6df618e45bb593ae42#body_text
is schema:about of	named entity 'RDW' named entity 'acute' named entity 'blood counts' named entity 'biomarkers' named entity 'complete blood counts' named entity 'RDW' named entity 'risk factor' named entity 'hypertension' named entity 'reference interval' named entity 'RDW' named entity 'RDW' named entity 'medRxiv' named entity 'RDW' named entity 'age cohort' named entity 'COVID-19' named entity 'coagulopathy' named entity 'mortality risk' named entity 'medRxiv' named entity 'critical care' named entity 'medRxiv' named entity 'medRxiv' named entity 'RDW' named entity 'RDW' named entity 'mortality risk' named entity 'RDW' named entity 'RDW' named entity 'BWH' named entity 'platelet' named entity 'RDW' named entity 'RDW' named entity 'reference interval' named entity 'RDW' named entity 'RDW' named entity 'coefficient of variation' named entity 'mortality rate' named entity 'complete blood counts' named entity 'SARS-CoV-2' named entity 'medRxiv' named entity 'RDW' named entity 'leukopenia' named entity 'SARS-CoV-2' named entity 'D-Dimer' named entity 'p-value' named entity 'RDW' named entity 'peer review' named entity '2.25' named entity 'relative risk' named entity 'all-cause mortality' named entity 'statistical analysis' named entity 'D-Dimer' named entity 'bioMerieux' named entity 'respiratory illness' named entity 'RDW' named entity 'ICU' named entity 'clinical laboratory' named entity 'mortality rate' named entity 'RDW' named entity 'critical care' named entity 'RDW' named entity 'COVID' named entity 'lymphocyte count' named entity 'RDW' named entity 'RDW' named entity 'RDW' named entity 'relative risk' named entity 'RDW' named entity 'morbidity' named entity 'inflammation' named entity 'automated hematology' named entity 'RDW' named entity 'RDW' named entity 'RDW' named entity 'D-Dimer' named entity 'risk ratio'

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