About: Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route

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About: Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route
Creator	Kumbar, Mahantesh Shettar, Arun Hosakeri, Joy Kinnal, Shivashankar Patil, Sangamesh Toragalmath, Shivakumar
Source	Elsevier; Medline; PMC
abstract	Abstract Methoxy and tert-butyl substituted carboxamide, carboxylic acid and hydrazone Schiff base groups have been assembled into our newly designed fluorenone based ligands and prepared coordination compounds of some first row transition metals and characterized thoroughly with spectroscopic (1H and 13C NMR, IR, GC–MS, UV–Vis), analytical, TGA and molar conductance measurements. The stoichiometry of all the metal complexes is found to be 1: 2 (M: L2) with the general formula, [M(L)2], where L is a singly deprotonated ligand and the geometry of all the metal complexes is found to be octahedral. Ligands and their metal complexes successfully cleaved the pBR322 plasmid DNA and in case of anticancer activity against MCF–7 (human breast adenocarcinoma) cell line, the synthesized compounds found to exhibit excellent activity with prominent apoptotic effect which is characterized by cell shrinkage, cell breakage and turgidity and results were compared with the standard drug cisplatin. Very significant anticancer activity was observed for compounds L1H, Cu(L1)2, Cu(L2)2, Ni(L1)2 and Ni(L2)2 with IC50 value of <10 μgmL−1. Molecular docking studies were performed to assess the bonding mode of synthesized compounds. In case of antioxidant activity study, the compounds L1H, Ni(L1)2, Cu(L1)2, Cu(L2)2 and Ni(L2)2 exhibited significant scavenging activity with good percentage when compared with remaining tested compounds.
has issue date	2020-03-07(xsd:dateTime)
bibo:doi	10.1016/j.jorganchem.2020.121219
bibo:pmid	32214459
has license	els-covid
sha1sum (hex)	0a04d377a83b28dbc0d97c90acd829255796f69c
schema:url	https://doi.org/10.1016/j.jorganchem.2020.121219
resource representing a document's title	Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route
has PubMed Central identifier	PMC7094295
has PubMed identifier	32214459
schema:publication	J Organomet Chem
resource representing a document's body	covid:0a04d377a83b28dbc0d97c90acd829255796f69c#body_text
is schema:about of	named entity 'PRE' named entity 'derived' named entity 'metal complexes' named entity 'DERIVED' named entity 'ACTIVITY' named entity 'PROOF' named entity 'ANTICANCER' named entity 'ROUTE' named entity 'STUDIES' named entity 'JOURNAL ' named entity 'LIGANDS' named entity 'POLYCYCLIC' named entity 'METAL COMPLEXES' named entity 'AROMATIC COMPOUND' named entity 'NOVEL' named entity 'aromatic compound' named entity 'ligands' named entity 'DPPH' named entity 'metal complexes' named entity 'mitochondrial' named entity '3,5' named entity 'developed and tested' named entity 'UV-Vis' named entity 'ligands' named entity 'chloroform' named entity 'raw materials' named entity 'formazan' named entity 'MCF-7' named entity 'Agarose gel' named entity 'elemental analyses' named entity 'cell line' named entity 'pH 8' named entity 'smallpox' named entity 'bond order' named entity 'MCF-7' named entity 'molar' named entity 'Experimental results' named entity 'Platinum' named entity 'mmol' named entity 'experimental results' named entity 'active site' named entity 'crystal structure' named entity 'oxygen' named entity 'transition metal' named entity 'electrophoresis' named entity 'carboxylic acid' named entity 'ligand' named entity 'dose-response curves' named entity 'methanol' named entity 'DMSO' named entity 'room temperature' named entity 'small molecules' named entity 'measles' named entity 'standard drug' named entity 'absorbance' named entity 'incubation' named entity 'fluorenone' named entity 'protein' named entity 'tumor cells' named entity 'cell culture' named entity 'ppm' named entity 'cisplatin' named entity '3, 4' named entity 'Antioxidant activity' named entity 'dye' named entity 'FT-IR' named entity 'hydrazone' named entity 'sars' named entity 'anticancer drug' named entity 'specific sites' named entity 'molar' named entity 'ppm' named entity 'DPPH' named entity 'fluorene' named entity 'current research' named entity 'ion'

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