About: TNF-α − 308 G > A and IFN-γ + 874 A > T gene polymorphisms in Egyptian patients with lupus erythematosus

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About: TNF-α − 308 G > A and IFN-γ + 874 A > T gene polymorphisms in Egyptian patients with lupus erythematosus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TNF-α − 308 G > A and IFN-γ + 874 A > T gene polymorphisms in Egyptian patients with lupus erythematosus
Creator	Al-Kholy, Wfaa Elsaid, Afaf Elshazli, Rami Fathy, Hend Settin, Ahmad Sleem, Aml
Source	PMC
abstract	BACKGROUND: Systemic lupus erythematosus (SLE) is associated with immunogenetic factors. This study was planned to test for the association of TNF-α − 308 and IFN-γ + 874 gene polymorphisms with susceptibility and severity of SLE in Egyptian cases. SUBJECTS AND METHODS: This is a case controlled study including 125 Egyptian cases with SLE in addition to 112 healthy unrelated individuals from the same locality. For all participants, TNF-α − 308 G > A and IFN-γ + 874 A > T genetic polymorphisms were characterized using the PCR technique. RESULTS: Cases with SLE showed a significantly higher TNF-α − 308 A allele carriage rate (AA + GA genotypes) compared to controls (26.4% vs. 12.5%, p = 0.009, OR = 2.51, 95% CI = 1.26–4.99). These cases showed also a significantly higher carriage rate for the IFN-γ + 874 T allele (AT + TT genotypes) compared to controls (47.2% vs. 32.1%, p = 0.02, OR = 1.89, 95% CI = 1.11–3.21). Comparing age, gender, and disease severity presented by nephritis class, activity and chronicity indices in cases carrying the TNF-α − 308 A allele and in cases carrying IFN-γ + 874 T allele versus others showed no significant difference (p > 0.05). CONCLUSIONS: TNF-α − 308 A and IFN-γ + 874 T allele carriage are associated with susceptibility but not severity of SLE in Egyptian subjects.
has issue date	2016-06-04(xsd:dateTime)
bibo:doi	10.1016/j.mgene.2016.06.002
bibo:pmid	27331019
has license	cc-by-nc-nd
sha1sum (hex)	0a1f43c04e0e22fb6efbd94611920bc9680d7ae3
schema:url	https://doi.org/10.1016/j.mgene.2016.06.002
resource representing a document's title	TNF-α − 308 G > A and IFN-γ + 874 A > T gene polymorphisms in Egyptian patients with lupus erythematosus
has PubMed Central identifier	PMC4909826
has PubMed identifier	27331019
schema:publication	Meta Gene
resource representing a document's body	covid:0a1f43c04e0e22fb6efbd94611920bc9680d7ae3#body_text
is schema:about of	named entity 'For' named entity 'controls' named entity 'IFN-γ' named entity 'IFN-γ' named entity 'TNF-α' named entity 'individuals' named entity 'case' named entity 'susceptibility' named entity 'allele' covid:arg/0a1f43c04e0e22fb6efbd94611920bc9680d7ae3 named entity 'ANT' named entity 'participants' named entity 'polymorphisms' named entity 'activity' named entity 'gender' named entity 'PCR' named entity 'Cases' named entity 'nephritis' named entity 'carriage' named entity 'genotypes' named entity 'SLE' named entity 'nephritis' named entity 'genotypes' named entity 'polymorphisms' named entity 'SLE' named entity 'IFN-γ' named entity 'polymorphisms' named entity 'mesangial' named entity 'inflammatory responses' named entity 'autoimmune disorders' named entity 'polymorphisms' named entity 'kidney disease' named entity 'TNF-α' named entity 'complex disease' named entity 'SLE' named entity 'Vital organs' named entity 'IFN-γ' named entity 'Italian' named entity 'adhesion molecules' named entity 'genotype' named entity 'SLE' named entity 'genetic polymorphisms' named entity 'significant difference' named entity 'ethidium bromide' named entity 'genetic equilibrium' named entity 'cytokine' named entity 'genotype' named entity 'INF-γ' named entity 'cytokine' named entity 'SLE' named entity 'tumor necrosis factor alpha' named entity 'pro-inflammatory cytokine' named entity 'meta-analysis' named entity 'TNF-α' named entity '95% CI' named entity 'polymerase chain reaction' named entity 'TNF-α' named entity 'SLE' named entity 'PCR' named entity 'cytokines' named entity 'polymorphisms' named entity 'SLE' named entity 'INF-γ' named entity 'TNF-α' named entity 'Caucasian' named entity '0.01' named entity 'SPSS' named entity 'genotype' named entity 'immunomodulatory' named entity 'autoimmune' named entity 'mutation' named entity 'pro-inflammatory cytokine' named entity 'genotypes' named entity 'gene' named entity 'class III' named entity 'single-nucleotide polymorphism'

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