About: Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus
Creator	Compans, R Li, W Mohan, G Yang, C Ye, L
Source	PMC
abstract	In addition to its surface glycoprotein (GP(1,2)), Ebola virus (EBOV) directs the production of large quantities of a truncated glycoprotein isoform (sGP) that is secreted into the extracellular space. The generation of secreted antigens has been studied in several viruses and suggested as a mechanism of host immune evasion through absorption of antibodies and interference with antibody-mediated clearance. However such a role has not been conclusively determined for the Ebola virus sGP. In this study, we immunized mice with DNA constructs expressing GP(1,2) and/or sGP, and demonstrate that sGP can efficiently compete for anti-GP(12) antibodies, but only from mice that have been immunized by sGP. We term this phenomenon “antigenic subversion”, and propose a model whereby sGP redirects the host antibody response to focus on epitopes which it shares with membrane-bound GP(1,2), thereby allowing it to absorb anti-GP(1,2) antibodies. Unexpectedly, we found that sGP can also subvert a previously immunized host's anti-GP(1,2) response resulting in strong cross-reactivity with sGP. This finding is particularly relevant to EBOV vaccinology since it underscores the importance of eliciting robust immunity that is sufficient to rapidly clear an infection before antigenic subversion can occur. Antigenic subversion represents a novel virus escape strategy that likely helps EBOV evade host immunity, and may represent an important obstacle to EBOV vaccine design.
has issue date	2012-12-13(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003065
bibo:pmid	23271969
has license	cc-by
sha1sum (hex)	0a24f22d8d49dc503c52d43dbc51459fc06fbb14
schema:url	https://doi.org/10.1371/journal.ppat.1003065
resource representing a document's title	Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus
has PubMed Central identifier	PMC3521666
has PubMed identifier	23271969
schema:publication	PLoS Pathog
resource representing a document's body	covid:0a24f22d8d49dc503c52d43dbc51459fc06fbb14#body_text
is schema:about of	named entity 'sGP' named entity 'efficiently' named entity 'antibodies' named entity 'glycoprotein' named entity 'absorb' named entity 'term' named entity 'sGP' named entity 'Ebola virus' named entity 'host' named entity 'strategy' named entity 'Host' named entity 'Immune' named entity 'IMMUNITY' named entity 'ANTIBODY' named entity 'ESCAPE' named entity 'RESPONSE' named entity 'MEDIATED' named entity 'HELPS' named entity 'ALLOWING' named entity 'CLEAR' named entity 'INFECTION' covid:arg/0a24f22d8d49dc503c52d43dbc51459fc06fbb14 named entity 'SUFFICIENT' named entity 'OBSTACLE' named entity 'VIRUSES' named entity 'BUT' named entity 'SHARES' named entity 'MEMBRANE' named entity 'RAPIDLY' named entity 'VACCINOLOGY' named entity 'LARGE' named entity 'RESPONSE TO' named entity 'NOVEL' named entity 'IMMUNE EVASION' named entity 'HOST' named entity 'EXTRACELLULAR SPACE' named entity 'MECHANISM' named entity 'HAVE' named entity 'TRUNCATED' named entity '27S' named entity 'QUANTITIES' named entity 'MODEL' named entity 'FOCUS' named entity 'PHENOMENON' named entity 'INTERFERENCE' named entity 'ROLE' named entity 'RESULTING IN' named entity 'IMMUNE EVASION' named entity 'FINDING' named entity 'HOST' named entity 'PREVIOUSLY' named entity 'STUDY' named entity 'RELEVANT' named entity 'OCCUR' named entity 'REACTIVITY' named entity 'REPRESENT' named entity 'ELICITING' named entity 'ITS' named entity 'VACCINE DESIGN' named entity 'DETERMINED' named entity 'ROBUST' named entity 'ADDITION' named entity 'IMPORTANT' named entity 'IMMUNIZED' named entity 'ABSORB' named entity 'CROSS' named entity 'COMPETE' named entity 'MICE' named entity 'LIKELY' named entity 'DNA' named entity 'SECRETED' named entity 'ANTIGENS' named entity 'SGP' named entity 'HOST IMMUNITY' named entity 'GENERATION' named entity 'NOVEL' named entity 'ISOFORM'

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