About: In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections
Creator	Yang, D Yuen, K Wang, Y Kao, Ryt Wong, Ssw
source	Medline; PMC
abstract	Candida is the most common fungal pathogen of humans worldwide and has become a major clinical problem because of the growing number of immunocompromised patients, who are susceptible to infection. Moreover, the number of available antifungals is limited, and antifungal-resistant Candida strains are emerging. New and effective antifungals are therefore urgently needed. Here, we discovered a small molecule with activity against Candida spp. both in vitro and in vivo. We screened a library of 50,240 small molecules for inhibitors of yeast-to-hypha transition, a major virulence attribute of Candida albicans. This screening identified 20 active compounds. Further examination of the in vitro antifungal and anti-biofilm properties of these compounds, using a range of Candida spp., led to the discovery of SM21, a highly potent antifungal molecule (minimum inhibitory concentration (MIC) 0.2 – 1.6 µg/ml). In vitro, SM21 was toxic to fungi but not to various human cell lines or bacterial species and was active against Candida isolates that are resistant to existing antifungal agents. Moreover, SM21 was relatively more effective against biofilms of Candida spp. than the current antifungal agents. In vivo, SM21 prevented the death of mice in a systemic candidiasis model and was also more effective than the common antifungal nystatin at reducing the extent of tongue lesions in a mouse model of oral candidiasis. Propidium iodide uptake assay showed that SM21 affected the integrity of the cell membrane. Taken together, our results indicate that SM21 has the potential to be developed as a novel antifungal agent for clinical use.
has issue date	2014-01-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0085836
bibo:pmid	24465737
has license	cc-by
sha1sum (hex)	0a4a2763f35864555a20b296c1daf1614f09e28f
schema:url	https://doi.org/10.1371/journal.pone.0085836
resource representing a document's title	In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections
has PubMed Central identifier	PMC3899067
has PubMed identifier	24465737
schema:publication	PLoS One
resource representing a document's body	covid:0a4a2763f35864555a20b296c1daf1614f09e28f#body_text
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