About: Coinfections of the Respiratory Tract: Viral Competition for Resources

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coinfections of the Respiratory Tract: Viral Competition for Resources
Creator	Pinky, Lubna Dobrovolny, Hana
topic	covid:0a851d4005336287cd41901a8fcd0ba3bab686c9#this
Source	Medline; PMC
abstract	Studies have shown that simultaneous infection of the respiratory tract with at least two viruses is common in hospitalized patients, although it is not clear whether these infections are more or less severe than single virus infections. We use a mathematical model to study the dynamics of viral coinfection of the respiratory tract in an effort to understand the kinetics of these infections. Specifically, we use our model to investigate coinfections of influenza, respiratory syncytial virus, rhinovirus, parainfluenza virus, and human metapneumovirus. Our study shows that during coinfections, one virus can block another simply by being the first to infect the available host cells; there is no need for viral interference through immune response interactions. We use the model to calculate the duration of detectable coinfection and examine how it varies as initial viral dose and time of infection are varied. We find that rhinovirus, the fastest-growing virus, reduces replication of the remaining viruses during a coinfection, while parainfluenza virus, the slowest-growing virus is suppressed in the presence of other viruses.
has issue date	2016-05-19(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0155589
bibo:pmid	27196110
has license	cc-by
sha1sum (hex)	0a851d4005336287cd41901a8fcd0ba3bab686c9
schema:url	https://doi.org/10.1371/journal.pone.0155589
resource representing a document's title	Coinfections of the Respiratory Tract: Viral Competition for Resources
has PubMed Central identifier	PMC4873262
has PubMed identifier	27196110
schema:publication	PLoS One
resource representing a document's body	covid:0a851d4005336287cd41901a8fcd0ba3bab686c9#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0a851d4005336287cd41901a8fcd0ba3bab686c9
is schema:about of	named entity 'HOST CELLS' named entity 'SINGLE' named entity 'MODEL' named entity 'STUDIES' named entity 'DOSE' named entity 'COMMON' named entity 'INTERACTIONS' named entity 'AVAILABLE' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'HOW' named entity 'TIME' named entity 'INFECTIONS' named entity 'SIMULTANEOUS' named entity 'DETECTABLE' named entity 'VIRAL' named entity 'BEING' named entity 'NEED FOR' named entity 'EFFORT' named entity 'CLEAR' named entity 'BLOCK' named entity 'UNDERSTAND' named entity 'HOSPITALIZED PATIENTS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'VIRUSES' named entity 'VARIES' named entity 'OUR' named entity 'RHINOVIRUS' named entity 'INITIAL' named entity 'COMPETITION' named entity 'RESPIRATORY TRACT' named entity 'RESPIRATORY TRACT' named entity 'GROWING' named entity 'COINFECTION' named entity 'PRESENCE OF' named entity 'VIRAL INTERFERENCE' named entity 'PARAINFLUENZA VIRUS' named entity 'HAVE' named entity 'STUDY' named entity 'USE' named entity 'INFECTION' named entity 'REMAINING' named entity 'TO CALCULATE' named entity 'INFLUENZA' named entity 'MATHEMATICAL MODEL' named entity 'TO INFECT' named entity 'VIRAL' named entity 'RESOURCES' named entity 'VIRUS' named entity 'TO INVESTIGATE' named entity 'DYNAMICS' named entity 'SUPPRESSED' named entity 'IMMUNE RESPONSE' named entity 'DURATION' named entity 'SEVERE' named entity 'REPLICATION' named entity 'KINETICS' named entity 'THESE' covid:arg/0a851d4005336287cd41901a8fcd0ba3bab686c9 named entity 'respiratory tract' named entity 'influenza' named entity 'immune response' named entity 'virus' named entity 'viruses' named entity 'virus infections' named entity 'respiratory syncytial virus' named entity 'Competition for Resources' named entity 'Viral' named entity 'virus-cell interactions' named entity 'host cells' named entity 'cell regeneration' named entity 'mathematical modeling' named entity 'viral infections' named entity 'viruses' named entity 'infection' named entity 'H3N2' named entity 'inoculum' named entity 'influenza infection' named entity 'virus infection'

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