About: A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine

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About: A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine
Creator	Kesl, Lyle Welter, Mark Howard, John Jilka, Joseph Streatfield, Stephen Lamphear, Barry
Source	Elsevier; Medline; PMC
abstract	Abstract Recombinant plant expression systems offer a means to produce large quantities of selected antigens for subunit vaccines. Cereals are particularly well-suited expression vehicles since the expressed proteins can be stored at relatively high concentrations for extended periods of time without degradation and dry seed can be formulated into oral vaccines suitable for commercial applications. A subunit vaccine candidate directed against porcine transmissible gastroenteritis virus and expressed in corn seed has been developed for oral delivery to swine. Here, we show that this vaccine, when administered to previously sensitized gilts, can boost neutralizing antibody levels in the animals’ serum, colostrum and milk. Thus, this vaccine candidate is effective at boosting lactogenic immunity and is appropriate to pursue through large-scale field trials preceding commercialization.
has issue date	2004-06-23(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2003.11.066
bibo:pmid	15193404
has license	els-covid
sha1sum (hex)	0aab3823dd11220b278bb89cc745bf21ad294b99
schema:url	https://doi.org/10.1016/j.vaccine.2003.11.066
resource representing a document's title	A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine
has PubMed Central identifier	PMC7126512
has PubMed identifier	15193404
schema:publication	Vaccine
resource representing a document's body	covid:0aab3823dd11220b278bb89cc745bf21ad294b99#body_text
is schema:about of	named entity 'subunit vaccine' named entity 'expression' named entity 'vaccine' named entity 'sensitized' named entity 'boosting' named entity 'expressed' named entity 'proteins' named entity 'quantities' named entity 'gastroenteritis' named entity 'vaccines' named entity 'ANTIGENS' named entity 'BOOST' named entity 'SUITABLE' named entity 'SYSTEMS' named entity 'APPROPRIATE' named entity 'TO PRODUCE' named entity 'SCALE' named entity 'SWINE' named entity 'DIRECTED' named entity 'LEVELS' named entity 'CEREALS' named entity 'EXPRESSION' named entity 'COLOSTRUM' named entity 'SUBUNIT VACCINE CANDIDATE' named entity 'SUBUNIT VACCINES' named entity 'CORN' named entity 'FIELD TRIALS' named entity 'LARGE' named entity 'SERUM' named entity 'OFFER' named entity 'HIGH' covid:arg/0aab3823dd11220b278bb89cc745bf21ad294b99 named entity 'ANIMALS' named entity 'ORAL' named entity 'VACCINES' named entity 'EXTENDED' named entity 'PREVIOUSLY' named entity 'TIME' named entity 'MEANS' named entity 'PROTEINS' named entity 'BOOSTING' named entity 'QUANTITIES' named entity 'PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'APPLICATIONS' named entity 'MILK' named entity 'RECOMBINANT' named entity 'NEUTRALIZING ANTIBODY' named entity 'BASED' named entity 'CORN-' named entity 'PLANT' named entity 'ANIMAL VACCINES' named entity 'DELIVERY SYSTEM' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS VACCINE' named entity 'SWINE' named entity 'ORAL' named entity 'SEED' named entity 'PRECEDING' named entity 'EFFECTIVE' named entity 'VACCINE CANDIDATE' named entity 'HERE' named entity 'EXPRESSED' named entity 'CONCENTRATIONS' named entity 'STORED' named entity 'IMMUNITY' named entity 'VEHICLES' named entity 'SELECTED' named entity 'DRY SEED' named entity 'ORAL DELIVERY' named entity 'IMMUNITY' named entity 'COMMERCIALIZATION' named entity 'DEGRADATION' named entity 'PERIODS' named entity 'ADMINISTERED' named entity 'COMMERCIAL' named entity 'VACCINE' named entity 'gastroenteritis'

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