About: Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function

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About: Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function
Creator	Ariumi, Yasuo Kuroki, Misao Yasuda-Inoue, Mariko
Source	Elsevier; Medline; PMC
abstract	Abstract RNA helicase plays an important role in host mRNA and viral mRNA transcription, transport, and translation. Many viruses utilize RNA helicases in their life cycle, while human immunodeficiency virus type 1 (HIV-1) does not encode an RNA helicase. Thus, host RNA helicase has been involved in HIV-1 replication. Indeed, DDX1 and DDX3 DEAD-box RNA helicases are known to be required for efficient HIV-1 Rev-dependent RNA export. However, it remains unclear whether distinct DDX RNA helicases cross-talk and cooperate to modulate the HIV-1 Rev function. In this study, we noticed that distinct DDX RNA helicases, including DDX1, DDX3, DDX5, DDX17, DDX21, DDX56, except DDX6, bound to the Rev protein and they colocalized with Rev in nucleolus or nucleus. In this context, these DEAD-box RNA helicases except DDX6 markedly enhanced the HIV-1 Rev-dependent RNA export. Furthermore, DDX3 interacted with DDX5 and synergistically enhanced the Rev function. As well, combination of other distinct DDX RNA helicases cooperated to stimulate the Rev function. Altogether, these results suggest that distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function.
has issue date	2013-05-17(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2013.04.016
bibo:pmid	23608157
has license	els-covid
sha1sum (hex)	0ac8a7f82aad93ce05c17848784cdb2dc06aa44f
schema:url	https://doi.org/10.1016/j.bbrc.2013.04.016
resource representing a document's title	Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function
has PubMed Central identifier	PMC7092829
has PubMed identifier	23608157
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:0ac8a7f82aad93ce05c17848784cdb2dc06aa44f#body_text
is schema:about of	named entity 'export' named entity 'Rev' named entity 'HIV-1' named entity 'modulate' named entity 'EFFICIENT' named entity 'DDX5' named entity 'REV PROTEIN' named entity 'EXCEPT' named entity 'DEPENDENT' named entity 'RESULTS' named entity 'HUMAN IMMUNODEFICIENCY VIRUS TYPE 1' named entity 'DDX21' named entity 'MRNA TRANSCRIPTION' named entity 'THEIR' named entity 'INCLUDING' named entity 'THESE' named entity 'DDX1' named entity 'HIV-1 REPLICATION' named entity 'IMPORTANT' named entity 'ROLE' named entity 'HOST' named entity 'NUCLEOLUS' named entity 'BOUND' named entity 'HIV-1' named entity 'REQUIRED' named entity 'CONTEXT' named entity 'FUNCTION' named entity 'VIRUSES' named entity 'DDX3' named entity 'RNA' named entity 'UNCLEAR' named entity 'LIFE CYCLE' named entity 'STIMULATE' named entity 'DDX17' named entity 'INTERACTED' named entity 'S T' named entity 'KNOWN' named entity 'ENHANCED' named entity 'RNA HELICASES' named entity 'INVOLVED' named entity 'FUNCTION' named entity 'DEAD-BOX RNA HELICASES' named entity 'MRNA' named entity 'MARKEDLY' named entity 'ENCODE' named entity 'EXPORT' named entity 'HIV-1' named entity 'MODULATE' named entity 'PLAYS' named entity 'MODULATE' named entity 'DDX' named entity 'DOES NOT' named entity 'TRANSPORT' named entity 'REV' named entity 'SUGGEST' named entity 'PROTEIN ' named entity 'RNA HELICASE' named entity 'CROSS-TALK' named entity 'TRANSLATION' named entity 'VIRAL MRNA' named entity 'DDX56' named entity 'NUCLEUS' named entity 'DISTINCT' named entity 'DDX' named entity 'COMBINATION' named entity 'DEAD-BOX RNA HELICASES' named entity 'DISTINCT' named entity 'REV' named entity 'DDX6' named entity 'STUDY' covid:arg/0ac8a7f82aad93ce05c17848784cdb2dc06aa44f named entity 'export' named entity 'Rev' named entity 'DDX5' named entity 'HIV-1' named entity 'host' named entity 'Rev' named entity 'viral' named entity 'cooperated'

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