About: Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity

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About: Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity
Creator	Alamdari, Naimeh Alipour, Shahriar Alivand, Mohammadreza Farsi, Farnaz Irandoost, Pardis Jafarabadi, Mohammad Roshangar, Leila Roshanravan, Neda Shidfar, Farzad Vafa, Mohammadreza
source	PMC
abstract	BACKGROUND: Obesity has reached an alarming rate worldwide. Promoting thermogenesis via increasing the function of brown adipose tissue (BAT) or white adipose tissue (WAT) browning has been proposed as a new protective approach against obesity. The goal of this study was to evaluate the effects of Royal Jelly (RJ) and tocotrienol rich fraction (TRF) on BAT activation and WAT browning during calorie restriction diet (CRD) in obesity model. METHODS: In this experimental study, 50 obese Wistar rats were randomly divided into 5 groups and then received one of the following treatments for a period of 8-week: High-fat diet (HFD), CRD, RJ + CRD, TRF + CRD, and RJ + TRF + CRD. Effects of RJ and TRF, individually and in combination on body weight and the expression of key thermoregulatory genes in WAT and BAT were examined by quantitative real-time (qRT-PCR). Also, morphological alterations were assessed by hematoxylin and eosin staining. RESULTS: RJ (− 67.21 g ±4.84 g) and RJ + TRF (− 73.29 g ±4.51 g) significantly reduced weight gain relative to the CRD group (− 40.70 g ±6.50 g, P < 0.001). In comparison with the CRD group, RJ and RJ + TRF remarkably enhanced the uncoupling protein1 (UCP1) expression in WAT (5.81, 4.72 fold, P < 0.001) and BAT (4.99, 4.75 fold, P < 0.001). The expression of PR domain containing 16(PRDM 16), cAMP response element-binding protein1 (CREB1), P38 mitogen-activated protein kinases (P38MAPK), and Bone morphogenetic protein8B (BMP8B) have significantly increased following RJ and RJ + TRF treatments (P < 0.001). However, the expression levels of CCAAT/enhancer-binding protein beta (CEBPβ) and Bone morphogenetic protein7 (BMP7) did not remarkably change. Multilocular beige cells in WAT and compacted dense adipocytes were also observed in BAT of RJ and RJ + TRF received groups. TRF showed no substantial effects on the expression of the mentioned thermoregulatory genes and brown fat-like phenotype. CONCLUSION: Our results suggest that, Royal Jelly promotes thermogenesis and browning of WAT, contributing to an increase in energy expenditure. Thus, Royal Jelly may give rise to a novel dietary choice to attenuate obesity.
has issue date	2020-06-01(xsd:dateTime)
bibo:doi	10.1186/s12986-020-00458-8
has license	cc-by
sha1sum (hex)	0b0e4ab25933932cacf8ec0a48c43fc0b30f856e
schema:url	https://doi.org/10.1186/s12986-020-00458-8
resource representing a document's title	Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity
has PubMed Central identifier	PMC7266117
schema:publication	Nutr Metab (Lond)
resource representing a document's body	covid:0b0e4ab25933932cacf8ec0a48c43fc0b30f856e#body_text
is schema:about of	named entity 'TRF' named entity 'obese' named entity 'obesity' named entity 'WORLDWIDE' named entity 'ALARMING' named entity 'STUDY' named entity 'EFFECTS' covid:arg/0b0e4ab25933932cacf8ec0a48c43fc0b30f856e named entity 'fraction' named entity 'reached' named entity 'calorie' named entity 'browning' named entity 'brown adipose tissue' named entity 'obesity' named entity 'BAT' named entity 'CRD' named entity 'BAT' named entity 'white fat' named entity 'obesity treatment' named entity 'peroxisome' named entity 'preadipocytes' named entity 'P38 mitogen-activated protein kinases' named entity 'adipose tissues' named entity 'energy expenditure' named entity 'CRD' named entity 'randomly selected' named entity 'energy expenditure' named entity 'reverse transcription' named entity 'WAT' named entity 'UCP-1' named entity 'expression levels' named entity 'PPARs' named entity 'beiging' named entity 'xylazine' named entity 'Qiagen' named entity 'BAT' named entity 'short duration' named entity 'CRD' named entity 'brown adipose tissue' named entity 'adipose tissue' named entity 'WAT' named entity 'UCP1' named entity 'thermogenesis' named entity 'PRDM16' named entity 'CRD' named entity 'energy expenditure' named entity 'CREB1' named entity 'body weight' named entity 'ad libitum' named entity 'UCP1' named entity 'intraperitoneal injection' named entity 'UCP1' named entity 'β-Actin' named entity 'thermogenic' named entity 'BAT' named entity 'weight loss' named entity 'obesity' named entity 'weight loss' named entity 'Gene expression' named entity 'PPARγ' named entity 'protein' named entity 'tocotrienol' named entity 'connective tissue' named entity 'BAT' named entity 'UCP1' named entity 'brown adipocytes' named entity 'ATP' named entity 'adipocytes' named entity 'adipose tissues' named entity 'PBS' named entity 'CRD' named entity 'calorie restriction' named entity 'obesity' named entity 'CRD'

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