About: Molecular gymnastics at the herpesvirus surface

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular gymnastics at the herpesvirus surface
Creator	Rey, Félix
Source	Medline; PMC
abstract	This review analyses recent structural results that provide clues about a possible molecular mechanism for the transmission of a fusogenic signal among the envelope glycoproteins of the herpes simplex virus on receptor binding by glycoprotein gD. This signal triggers the membrane-fusion machinery of the virus—contained in glycoproteins gB, gH and gL—to induce the merging of viral and cellular membranes, and to allow virus entry into target cells. This activating process parallels that of γ-retroviruses, in which receptor binding by the amino-terminal domain of the envelope protein activates the fusogenic potential of the virion in a similar way, despite the different organization of the envelope complexes of these two types of viruses. Therefore, the new structural results on the interaction of gD with its receptors might also provide insights into the mechanism of fusogenic signal transmission in γ-retroviruses. Furthermore, the fusion activation parallels with retroviruses, together with the recently reported structural homology of gB with the rhabdovirus envelope glycoprotein indicate that the complex entry apparatus of herpesviruses appears to be functionally related to that of simpler enveloped viruses.
has issue date	2006-08-01(xsd:dateTime)
bibo:doi	10.1038/sj.embor.7400807
bibo:pmid	17016458
has license	green-oa
sha1sum (hex)	0b1515138984b9f9f2d08a8aaedc388846b531d4
schema:url	https://doi.org/10.1038/sj.embor.7400807
resource representing a document's title	Molecular gymnastics at the herpesvirus surface
has PubMed Central identifier	PMC1618366
has PubMed identifier	17016458
schema:publication	EMBO reports
resource representing a document's body	covid:0b1515138984b9f9f2d08a8aaedc388846b531d4#body_text
is schema:about of	named entity 'This' named entity 'signal' named entity 'gD.' named entity 'glycoprotein' named entity 'INTERACTION' named entity 'INDUCE' named entity 'MECHANISM' named entity 'POTENTIAL' named entity 'VIRION' named entity 'COMPLEXES' named entity 'ACTIVATES' named entity 'ACTIVATION' named entity 'APPARATUS' named entity 'MEMBRANE' named entity 'REVIEW' named entity 'DIFFERENT' named entity 'ITS' named entity 'RELATED' named entity 'NEW' named entity 'FUSION' named entity 'CELLULAR' named entity 'MOLECULAR MECHANISM' named entity 'ORGANIZATION' named entity 'COMPLEX' named entity 'RHABDOVIRUS' named entity 'PROVIDE' covid:arg/0b1515138984b9f9f2d08a8aaedc388846b531d4 named entity 'CONTAINED IN' named entity 'STRUCTURAL HOMOLOGY' named entity 'ENTRY' named entity 'ACTIVATING' named entity 'HERPESVIRUSES' named entity 'POSSIBLE' named entity 'SIGNAL TRANSMISSION' named entity 'WAY' named entity 'VIRUS ENTRY' named entity 'MERGING' named entity 'RECEPTORS' named entity 'TYPES' named entity 'MEMBRANES' named entity 'RETROVIRUSES' named entity 'INSIGHTS' named entity 'RECENTLY' named entity 'RECEPTOR BINDING' named entity 'PROTEIN ' named entity 'ENVELOPE GLYCOPROTEIN' named entity 'MACHINERY' named entity 'VIRUSES' named entity 'TRIGGERS' named entity 'SIGNAL' named entity 'THESE' named entity 'PROCESS' named entity 'RESULTS' named entity 'SIMILAR' named entity 'REPORTED' named entity 'TRANSMISSION' named entity 'HERPES SIMPLEX VIRUS' named entity 'GLYCOPROTEIN' named entity 'VIRAL AND' named entity 'TARGET CELLS' named entity 'GLYCOPROTEINS' named entity 'ENVELOPE' named entity 'ENVELOPE PROTEIN' named entity 'STRUCTURAL' named entity 'DOMAIN' named entity 'RECENT' named entity 'VIRUS' named entity 'ABOUT' named entity 'TERMINAL' named entity 'ALLOW' named entity 'AMINO' named entity 'induce' named entity 'virus' named entity 'signal' named entity 'activates' named entity 'cellular membranes' named entity 'This' named entity 'protein' named entity 'glycoproteins' named entity 'receptors' named entity 'This'

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