About: Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Alpha-1 antitrypsin inhibits SARS-CoV-2 infection
Creator	Münch, Jan Kirchhoff, Frank Frick, Manfred Müller, Janis Ständker, Ludger Bozzo, Caterina Conzelmann, Carina Fois, Giorgio Groß, Rüdiger Hirschenberger, Maximilian Kleger, Alexander Klute, Susanne Knaff, Philip Lochbaum, Robin Lochnit, Günter Mailänder, Volker Preising, Nico Schumann, Christian Seidel, Alina Sparrer, Konstantin Stenger, Steffen Thal, Dietmar Weil, Tatjana Wettstein, Lukas Zech, Fabian
Source	BioRxiv
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). To identify factors of the respiratory tract that suppress SARS-CoV-2, we screened a peptide/protein library derived from bronchoalveolar lavage, and identified α1-antitrypsin (α1-AT) as specific inhibitor of SARS-CoV-2. α1-AT targets the viral spike protein and blocks SARS-CoV-2 infection of human airway epithelium at physiological concentrations. Our findings show that endogenous α1-AT restricts SARS-CoV-2 and repurposes α1-AT-based drugs for COVID-19 therapy.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1101/2020.07.02.183764
has license	biorxiv
sha1sum (hex)	0b2d488ca3f4f788888a7f91f921674b0a650339
schema:url	https://doi.org/10.1101/2020.07.02.183764
resource representing a document's title	Alpha-1 antitrypsin inhibits SARS-CoV-2 infection
schema:publication	bioRxiv
resource representing a document's body	covid:0b2d488ca3f4f788888a7f91f921674b0a650339#body_text
is schema:about of	named entity 'SPIKE PROTEIN' named entity 'INHIBITOR' named entity 'IDENTIFIED' named entity 'SARS-CoV-2' named entity 'Our' named entity 'targets' named entity 'infection' named entity 'protein' named entity 'cell lysates' named entity '100 %' named entity 'COVID-19' named entity 'innate immune defense' named entity 'infection' named entity 'lung' named entity 'COVID-19' named entity 'α1-' named entity 'specific' named entity 'inhibitor' named entity 'Alpha-1 antitrypsin' named entity 'protein' named entity 'spike protein' named entity 'physiological' named entity 'endogenous' named entity 'α1-antitrypsin' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Alpha-1 antitrypsin' named entity 'defensins' named entity 'SARS-CoV2' named entity 'antiviral' named entity 'IC50' named entity 'antiviral activity' named entity 'PBS' named entity 'septic shock' named entity 'Dutch' named entity 'aerosols' named entity 'MALDI-TOF-MS' named entity 'lung' named entity 'lungs' named entity 'cell lines' named entity 'spike protein' named entity 'G-protein' named entity 'Merck' named entity 'GraphPad Prism' named entity 'fixed and stained' named entity 'Merck Millipore' named entity 'apical surface' named entity 'PBS' named entity 'HEK293T cells' named entity 'multiple comparison' named entity 'mesylate' named entity 'IC50' named entity 'luciferase' named entity 'pseudovirus' named entity 'epithelial lining fluid' named entity 'human lung' named entity 'acetonitrile' named entity 'viral replication' named entity 'PBS' named entity 'reflectron'

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