About: Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection

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About: Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection
Creator	Jung, Kwonil Miyazaki, Ayako Saif, Linda
Source	Elsevier; Medline; PMC
abstract	Abstract Serotonin is a critical monoamine neurotransmitter molecule stored and released from enterochromaffin (EC) cells into the gut submucosa, transmitting the vomiting signal to the brain. We studied one mechanism by which vomiting is induced in pigs infected with porcine epidemic diarrhea virus (PEDV) by characterization of swine EC cells by immunohistochemistry. Conventional or gnotobiotic (Gn) 9-day-old pigs [PEDV-inoculated (n = 12); Mock (n = 14)] were inoculated orally (8.9–9.2 log10 genomic equivalents/pig) with PEDV PC21A strain or mock. This is the first identification of serotonin-positive EC cells in swine by immunohistochemistry and mainly in intestinal crypts, regardless of infection status. They were morphologically triangular-shaped or round cells with or without apical cytoplasmic extensions, respectively. At post-inoculation hour (PIH) 16 or 24, when vomiting was first or frequently observed, respectively, PEDV infection resulted in significantly reduced numbers of serotonin-positive EC cells in duodenum, mid-jejunum, ileum, or colon. However, two of three PEDV-inoculated Gn pigs that did not yet show vomiting at PIH 16 had numbers of serotonin-positive EC cells in duodenum, ileum and colon similar to those in the negative controls. These findings suggest that serotonin release from EC cells (increased serotonin levels) into the gut submucosa might occur early PEDV post-infection to stimulate the vagal afferent neurons, followed by vomiting. Serotonin might be involved in the mechanisms related to vomiting in PEDV-infected piglets. We also found that mid-jejunum was the primary site of acute PEDV infection, and that systemic innate and pro-inflammatory cytokine responses were induced during the acute stage of PEDV infection.
has issue date	2018-08-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2018.06.009
bibo:pmid	29909130
has license	els-covid
sha1sum (hex)	0b506e20788c168d572bf9e48a54cb4573eb6085
schema:url	https://doi.org/10.1016/j.rvsc.2018.06.009
resource representing a document's title	Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection
has PubMed Central identifier	PMC7111759
has PubMed identifier	29909130
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:0b506e20788c168d572bf9e48a54cb4573eb6085#body_text
is schema:about of	named entity 'CONVENTIONAL' named entity 'vomiting' named entity 'serotonin' named entity 'cells' named entity 'submucosa' named entity 'infection' named entity 'pig' named entity 'mechanisms' named entity 'transmitting' named entity 'involved' named entity 'pigs' named entity 'INFECTION' named entity 'ACUTE' named entity 'FOUND' named entity 'STORED' named entity 'ROUND CELLS' named entity 'THESE' named entity 'SIMILAR' named entity 'PIH' named entity 'POSITIVE' named entity 'NUMBERS' named entity 'SUBMUCOSA' named entity 'OCCUR' named entity 'NEGATIVE' named entity 'ILEUM' named entity 'THE GUT' named entity 'MID' named entity 'LEVELS' named entity 'THE BRAIN' named entity 'PIGS' named entity 'PRIMARY SITE' named entity 'CRITICAL' named entity 'OBSERVED' named entity 'HOUR' named entity 'REDUCED' named entity 'INTESTINES' named entity 'RESPONSES' named entity 'GENOMIC EQUIVALENTS' named entity 'REGARDLESS' named entity 'TRANSMITTING' named entity 'EARLY' named entity 'INVOLVED' covid:arg/0b506e20788c168d572bf9e48a54cb4573eb6085 named entity 'CYTOKINE ' named entity 'PIGS' named entity 'MONOAMINE' named entity 'VOMITING' named entity 'NEUROTRANSMITTER' named entity 'ACUTE' named entity 'DID' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'MOLECULE' named entity 'SUGGEST' named entity 'INDUCED' named entity 'DETECTION' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'SEROTONIN' named entity 'SERUM CYTOKINE' named entity 'INFECTED' named entity 'SEROTONIN RELEASE' named entity 'IS A' named entity 'CONVENTIONAL' named entity 'JEJUNUM' named entity 'INOCULATION' named entity 'POST' named entity 'FINDINGS' named entity 'CYTOKINE ' named entity 'RELEASED' named entity 'SITE OF' named entity 'MOCK' named entity 'STIMULATE' named entity 'COLON' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'INFECTION STATUS' named entity 'SHAPED' named entity 'SYSTEMIC' named entity 'SWINE' named entity 'FOLLOWED BY' named entity 'INFECTED'

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