About: Systematic Identification of Spontaneous Preterm Birth-Associated RNA Transcripts in Maternal Plasma

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Systematic Identification of Spontaneous Preterm Birth-Associated RNA Transcripts in Maternal Plasma
Creator	Chan, Oi Chim, Stephen Lee, Shara Lee, Wing Leung, Tak Ting, Yuen
source	Medline; PMC
abstract	BACKGROUND: Spontaneous preterm birth (SPB, before 37 gestational weeks) is a major cause of perinatal mortality and morbidity, but its pathogenesis remains unclear. Studies on SPB have been hampered by the limited availability of markers for SPB in predelivery clinical samples that can be easily compared with gestational age-matched normal controls. We hypothesize that SPB involves aberrant placental RNA expression, and that such RNA transcripts can be detected in predelivery maternal plasma samples, which can be compared with gestational age-matched controls. PRINCIPAL FINDINGS: Using gene expression microarray to profile essentially all human genes, we observed that 426 probe signals were changed by >2.9-fold in the SPB placentas, compared with the spontaneous term birth (STB) placentas. Among the genes represented by those probes, we observed an over-representation of functions in RNA stabilization, extracellular matrix binding, and acute inflammatory response. Using RT-quantitative PCR, we observed differences in the RNA concentrations of certain genes only between the SPB and STB placentas, but not between the STB and term elective cesarean delivery placentas. Notably, 36 RNA transcripts were observed at placental microarray signals higher than a threshold, which indicated the possibility of their detection in maternal plasma. Among them, the IL1RL1 mRNA was tested in plasma samples taken from 37 women. It was detected in 6 of 10 (60%) plasma samples collected during the presentation of preterm labor (≤32.9 weeks) in women eventually giving SPB, but was detected in only 1 of 27 (4%) samples collected during matched gestational weeks from women with no preterm labor (Fisher exact test, p = 0.00056). CONCLUSION: We have identified 36 SPB-associated RNA transcripts, which are possibly detectable in maternal plasma. We have illustrated that the IL1RL1 mRNA was more frequently detected in predelivery maternal plasma samples collected from women resulting in SPB than the gestational-age matched controls.
has issue date	2012-04-05(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0034328
bibo:pmid	22496790
has license	cc-by
sha1sum (hex)	0b9b177210a4b23ff4745f2717083ba047a9e770
schema:url	https://doi.org/10.1371/journal.pone.0034328
resource representing a document's title	Systematic Identification of Spontaneous Preterm Birth-Associated RNA Transcripts in Maternal Plasma
has PubMed Central identifier	PMC3320630
has PubMed identifier	22496790
schema:publication	PLoS One
resource representing a document's body	covid:0b9b177210a4b23ff4745f2717083ba047a9e770#body_text
is schema:about of	named entity 'CAUSE' named entity 'MATERNAL' named entity 'UNCLEAR' named entity 'MARKERS' named entity 'PLASMA' named entity 'IS A' named entity 'GESTATIONAL AGE' named entity 'CLINICAL' named entity 'DETECTED' named entity 'ABERRANT' named entity 'MATCHED' named entity 'RNA' named entity 'ITS' named entity 'BUT' named entity 'SAMPLES' named entity 'RNA' named entity 'maternal' named entity 'aberrant' named entity 'morbidity' named entity 'ASSOCIATED' named entity 'SPB' named entity 'GESTATIONAL WEEKS' named entity 'BACKGROUND' named entity 'SPONTANEOUS PRETERM BIRTH' named entity 'PERINATAL MORTALITY' named entity 'MATCHED NORMAL' named entity 'LIMITED' named entity 'EASILY' named entity 'HAVE' named entity 'AVAILABILITY OF' named entity 'PLACENTAL' named entity 'PATHOGENESIS' named entity 'TRANSCRIPTS' named entity 'SPONTANEOUS PRETERM BIRTH' named entity 'PLASMA' named entity 'TRANSCRIPTS' named entity 'IDENTIFICATION' named entity 'A MAJOR' named entity 'COMPARED' named entity 'STUDIES' named entity 'RNA EXPRESSION' named entity 'MATERNAL' named entity 'MORBIDITY' covid:arg/0b9b177210a4b23ff4745f2717083ba047a9e770 named entity 'transcripts' named entity 'RNA' named entity 'clinical samples' named entity 'Spontaneous preterm birth' named entity 'placental' named entity 'Spontaneous Preterm Birth' named entity 'Plasma' named entity 'plasma' named entity 'SPB' named entity 'pathogenesis' named entity 'down-regulated' named entity 'RNA extraction' named entity 'technical replicates' named entity 'down-regulated' named entity 'RNA' named entity 'RNA' named entity 'correlation coefficient' named entity 'placenta' named entity 'extracellular matrix' named entity 'reagent' named entity 'infection' named entity 'mRNA' named entity 'mRNA' named entity 'pathogenesis' named entity 'plasma' named entity 'plasma' named entity 'SPB' named entity 'microarray' named entity 'RNA extraction' named entity 'GAPDH' named entity 'IGF2' named entity 'TAGLN'

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