About: Snake Deltavirus Utilizes Envelope Proteins of Different Viruses To Generate Infectious Particles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Snake Deltavirus Utilizes Envelope Proteins of Different Viruses To Generate Infectious Particles
Creator	Kipar, Anja Martinez-Sobrido, Luis Hepojoki, Jussi Vapalahti, Olli Hetzel, Udo Szirovicza, Leonora
Source	Medline; PMC
abstract	Satellite viruses, most commonly found in plants, rely on helper viruses to complete their replication cycle. The only known example of a human satellite virus is the hepatitis D virus (HDV), and it is generally thought to require hepatitis B virus (HBV) to form infectious particles. Until 2018, HDV was the sole representative of the genus Deltavirus and was thought to have evolved in humans, the only known HDV host. The subsequent identification of HDV-like agents in birds, snakes, fish, amphibians, and invertebrates indicated that the evolutionary history of deltaviruses is likely much longer than previously hypothesized. Interestingly, none of the HDV-like agents were found in coinfection with an HBV-like agent, suggesting that these viruses use different helper virus(es). Here we show, using snake deltavirus (SDeV), that HBV and hepadnaviruses represent only one example of helper viruses for deltaviruses. We cloned the SDeV genome into a mammalian expression plasmid, and by transfection could initiate SDeV replication in cultured snake and mammalian cell lines. By superinfecting persistently SDeV-infected cells with reptarenaviruses and hartmaniviruses, or by transfecting their surface proteins, we could induce production of infectious SDeV particles. Our findings indicate that deltaviruses can likely use a multitude of helper viruses or even viral glycoproteins to form infectious particles. This suggests that persistent infections, such as those caused by arenaviruses and orthohantaviruses used in this study, and recurrent infections would be beneficial for the spread of deltaviruses. It seems plausible that further human or animal disease associations with deltavirus infections will be identified in the future.
has issue date	2020-03-17(xsd:dateTime)
bibo:doi	10.1128/mbio.03250-19
bibo:pmid	32184255
has license	cc-by
sha1sum (hex)	0baa9e01f27eceb210c79f80a13cc06b50c1830f
schema:url	https://doi.org/10.1128/mbio.03250-19
resource representing a document's title	Snake Deltavirus Utilizes Envelope Proteins of Different Viruses To Generate Infectious Particles
has PubMed Central identifier	PMC7078484
has PubMed identifier	32184255
schema:publication	mBio
resource representing a document's body	covid:0baa9e01f27eceb210c79f80a13cc06b50c1830f#body_text
is schema:about of	named entity 'invertebrates' named entity 'host cells' named entity 'coinfection' named entity 'plasmid' named entity 'HDV' named entity 'enveloped virus' named entity 'envelope proteins' named entity 'HDV' named entity 'taxa' named entity 'tissue tropism' named entity 'helper viruses' named entity 'HDV' named entity 'helper virus' named entity 'transfecting' named entity 'enveloped viruses' named entity 'hepatitis' named entity 'snake' named entity 'HDV' named entity 'cloned' named entity 'replication cycle' named entity 'snake' named entity 'evolutionary history' named entity 'Viruses' named entity 'Deltavirus' named entity 'initiation of transcription' named entity 'LCMV' named entity 'staining' named entity 'agar plates' named entity 'nucleoprotein' named entity 'coinfection' named entity 'HBV' named entity 'EcoRV' named entity 'cell lines' named entity 'microscope' named entity 'plasmid' named entity 'BSA' named entity 'viral species' named entity 'plasmid' named entity 'rat' named entity 'RNA extraction' named entity 'bovine serum albumin' named entity 'antibodies' named entity '1, 2' named entity 'glycoproteins' named entity 'reptarenavirus' named entity 'lung' named entity 'tryptone' named entity 'actin' named entity 'cell lines' named entity 'cell lines' named entity 'cell lines' named entity 'HBV' named entity 'HBV' named entity 'Δ cells' named entity 'room temperature' named entity 'infection' named entity 'helper virus' named entity 'virions' named entity 'cytoplasmic' named entity 'codon' named entity 'liver' named entity 'protein' named entity 'HDV' named entity 'DMEM' named entity 'ThermoFisher Scientific' named entity 'salivary glands' named entity 'sucrose' named entity 'transfected' named entity 'plasmid' named entity 'UGV' named entity 'plasmid' named entity 'plasmid' named entity 'restriction sites' named entity 'African green monkey' named entity 'carcinoma' named entity 'ThermoFisher Scientific'

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