About: Genes associated with liver damage signalling pathways may impact the severity of COVID-19 symptoms in Spanish and Italian populations

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Genes associated with liver damage signalling pathways may impact the severity of COVID-19 symptoms in Spanish and Italian populations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genes associated with liver damage signalling pathways may impact the severity of COVID-19 symptoms in Spanish and Italian populations
Creator	Batra, Jyotsna Moya, Leire Prof, A Farashi, Samaneh Janaththani, Panchadsaram Suravajhala, Prashanth
Source	BioRxiv
abstract	Aim The novel SARS-CoV-2 virus, which causes the COVID-19 disease, has infected more than 10 million people and caused 500K deaths worldwide. In Europe, over 2 million confirmed cases have been reported, while nearly 200K people have died from the disease. Despite strict containment measures in Spain and Italy after the first reported COVID-19 patient, these two countries have remained in the top five European nations with the highest mortality rate for over two months. We hypothesised that a genetic mechanism could partially explain the poor survival outcome observed in these two countries. Methods An extensive literature search to identify human candidate genes linked to SARS-CoV infection, host immune evasion and disease aggressiveness was carried out. Pathway analysis (IPA) was performed to select the most significantly associated canonical signalling pathways with the genes of interest. The genetic variants’ at these genes with ±1Mb flanking region was extracted (GRCh37/hg19 built). Over 80 million single nucleotide polymorphisms (SNPs) were analysed in genome-wide data of 2,504 individuals (1000 genomes, phase III, https://www.internationalgenome.org/). Principal component (PC) analysis was performed, ancestry by the whole genome was inferred and subsets of the regions of interest were extracted (PLINK v1.9b, http://pngu.mgh.harvard.edu/purcell/plink/). PC1 to PC20 values from five European ancestries, including the Spanish and Italian populations, were used for PC analysis. Gene function predictions were run with our genes of interest as a query to the GeneMANIA Cytoscape plugin (https://genemania.org/). Results A total of 437 candidate genes associated with SARS were identified, including 21 correlated with COVID-19 aggressiveness. The two most significant pathways associated with all 437 genes (Caveolar-mediated Endocytosis and MSP-RON Signalling) did not show any segregation at the population level. However, the most significant canonical pathway associated with genes linked to COVID-19 aggressiveness, the Hepatic Fibrosis and Hepatic Stellate Cell Activation, showed population-specific segregation. Both the Spanish and Italian populations clustered together from the rest of Europe. This was also observed for the Finnish population but in the opposite direction. These results suggest some of the severe COVID-19 cases reported in Spain and Italy could be partially explained by a pre-existing liver condition (especially liver cancer) and/or may lead to further COVID-19 related liver complications.
has issue date	2020-07-08(xsd:dateTime)
bibo:doi	10.1101/2020.07.03.179028
has license	biorxiv
sha1sum (hex)	0bda57a5160fbfa435ac572072635149687f5e78
schema:url	https://doi.org/10.1101/2020.07.03.179028
resource representing a document's title	Genes associated with liver damage signalling pathways may impact the severity of COVID-19 symptoms in Spanish and Italian populations
schema:publication	bioRxiv
resource representing a document's body	covid:0bda57a5160fbfa435ac572072635149687f5e78#body_text
is schema:about of	named entity 'mechanism' named entity 'top' named entity 'cases' named entity 'liver damage' named entity 'impact' named entity 'Genes' named entity 'CONTAINMENT' named entity 'partially' named entity 'cell receptor' named entity 'protein' named entity 'biomarker' named entity 'ubiquitination' named entity 'SARS-CoV-1' named entity 'Nsp4' named entity 'rRNA' named entity 'alcohol' named entity 'Tuscany' named entity 'mortality rate' named entity 'COVID-19' named entity 'COVID-19 disease' named entity 'liver damage' named entity 'mortality rate' named entity '2002 in China' named entity 'Italy' named entity 'Size of the population' named entity 'NF-kB' named entity '3,5' named entity 'lymphocyte' named entity 'infection' named entity 'European populations' named entity 'infection' named entity 'Italy' named entity 'protein' named entity 'ACE2' named entity 'public health' named entity 'viral particles' named entity 'pandemic in Italy' named entity 'COVID-19' named entity 'liver disease' named entity 'ACE2' named entity 'genomes' named entity 'cellular signalling' named entity 'Italy' named entity 'ACE2' named entity 'human lung' named entity 'epithelial' named entity 'COVID-19' named entity 'plasmids' named entity 'immunoblot' named entity 'glycosylation sites' named entity 'SARS-CoV' named entity 'infection' named entity 'liver' named entity 'COVID-19' named entity 'antiviral' named entity 'ACE2' named entity 'liver damage' named entity 'polysome' named entity 'signalling pathways' named entity 'transcriptomics' named entity 'WHO' named entity 'Europe' named entity 'Italian' named entity 'independent studies' named entity 'Co-IP' named entity 'Finland' named entity 'Calcineurin' named entity 'LDHA' named entity 'SARS' named entity 'virions' named entity 'SARS-CoV-2' named entity 'coronavirus disease' named entity 'SARS-CoV-2' named entity 'Genetics' named entity 'alcohol dehydrogenase' named entity 'virulence' named entity 'Hong Kong' named entity 'protein' named entity 'highly conserved'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software