About: Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine

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About: Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine
Creator	Chou, Chi-Yuan Chen, Yau-Hung Chen, Chiao-Che Lin, Chao-Hsiung Chu, Hsu-Feng Moses, David Tsai, Ying-Chieh
topic	covid:0be19bfb83d9eb0a6b6f1c7ce8b75a58d8b1ed6f#this
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal piglets. In Asia, modified live attenuated vaccines have been used to control PEDV infection in recent years. However, a new strain of PEDV that belongs to genogroup 2a appeared in the USA in 2013 and then quickly spread to Canada and Mexico as well as Asian and European countries. Due to the less effective protective immunity provided by the vaccines against this new strain, it has caused considerable agricultural and economic loss worldwide. The emergence of this new strain increases the importance of understanding PEDV as well as strategies for inhibiting it. Coronaviral proteases, including main proteases and papain-like proteases, are ideal antiviral targets because of their essential roles in viral maturation. Here we provide a first description of the expression, purification and structural characteristics of recombinant PEDV papain-like protease 2, moreover present our finding that 6-thioguanine, a chemotherapeutic drug, in contrast to its competitive inhibition on SARS- and MERS-CoV papain-like proteases, is a noncompetitive inhibitor of PEDV papain-like protease 2.
has issue date	2018-10-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2018.08.011
bibo:pmid	30138642
has license	els-covid
sha1sum (hex)	0be19bfb83d9eb0a6b6f1c7ce8b75a58d8b1ed6f
schema:url	https://doi.org/10.1016/j.antiviral.2018.08.011
resource representing a document's title	Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine
has PubMed Central identifier	PMC7113753
has PubMed identifier	30138642
schema:publication	Antiviral Research
resource representing a document's body	covid:0be19bfb83d9eb0a6b6f1c7ce8b75a58d8b1ed6f#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/0be19bfb83d9eb0a6b6f1c7ce8b75a58d8b1ed6f
is schema:about of	named entity 'EXTREME' named entity 'MODIFIED' named entity 'VIRAL MATURATION' named entity 'HERE' named entity 'UNDERSTANDING' named entity 'SARS' named entity 'LIVE' named entity 'CONTRAST' named entity 'MEXICO' named entity 'COMPETITIVE INHIBITION' named entity 'RECOMBINANT' named entity 'ROLES' named entity 'ASIAN' named entity 'INTESTINAL TRACT' named entity 'ECONOMIC LOSS' named entity 'DIARRHEA AND VOMITING' named entity 'EMERGENCE' named entity 'SPREAD' named entity 'MAIN' named entity '6-thioguanine' named entity 'protease' named entity 'infects' named entity 'diarrhea' named entity 'intestinal tract' named entity 'vaccines' named entity 'PAPAIN' covid:arg/0be19bfb83d9eb0a6b6f1c7ce8b75a58d8b1ed6f named entity 'CANADA' named entity 'INCREASES' named entity 'CAUSE' named entity 'RECENT' named entity 'PROTEASE 2' named entity 'DRUG' named entity 'PROVIDED' named entity 'INHIBITED' named entity 'PROTEASE 2' named entity 'STRUCTURAL' named entity 'STRATEGIES' named entity 'PAPAIN' named entity 'CONSIDERABLE' named entity 'ANTIVIRAL' named entity 'DUE TO' named entity 'HAVE' named entity 'DEHYDRATION' named entity 'PROTECTIVE IMMUNITY' named entity 'TARGETS' named entity 'INFECTION' named entity 'USED' named entity 'LIKE' named entity 'ATTENUATED VACCINES' named entity 'EXPRESSION' named entity 'PROVIDE' named entity 'PURIFICATION' named entity 'IS A' named entity 'INHIBITING' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'LIKE' named entity 'OUR' named entity 'INCLUDING' named entity 'DESCRIPTION' named entity 'IDEAL' named entity 'INHIBITOR' named entity 'ASIA' named entity 'VACCINES' named entity 'INFECTS' named entity 'THEIR' named entity 'CORONAVIRUS' named entity 'USA' named entity 'AGRICULTURAL' named entity 'EUROPEAN' named entity 'CHARACTERISTICS' named entity '6-THIOGUANINE' named entity 'WORLDWIDE'

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