About: Magnetic nanoparticle-based immunoassay for rapid detection of influenza infections by using an integrated microfluidic system

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About: Magnetic nanoparticle-based immunoassay for rapid detection of influenza infections by using an integrated microfluidic system Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Magnetic nanoparticle-based immunoassay for rapid detection of influenza infections by using an integrated microfluidic system
Creator	Chang, Chih-Peng Chang, Jui-Cheng Huang, Chih-Chia Hung, Lien-Yu Lee, Gwo-Bin Tsai, Yi-Che Yeh, Chen-Sheng
topic	covid:0c41ec48ace1522ef6efb0deca6a6f2864213bb5#this
Source	Elsevier; Medline; PMC
abstract	Magnetic manganese ferrite (MnFe(2)O(4)) nanoparticles with approximately 100 nm in diameter were used to improve the performance of an immunoassay for detecting influenza infections. The synthesized nanoparticles were tested for long-term storage to confirm the stability of their thermal decomposition process. Then, an integrated microfluidic system was developed to perform the diagnosis process automatically, including virus purification and detection. To apply these nanoparticles for influenza diagnosis, a micromixer was optimized to reduce the dead volume within the microfluidic chip. Furthermore, the mixing index of the micromixer could achieve as high as 97% in 2 seconds. The optical signals showed that this nanoparticle-based immunoassay with dynamic mixing could successfully achieve a detection limit of influenza as low as 0.007 HAU. When compared with the 4.5-μm magnetic beads, the optical signals of the MnFe(2)O(4) nanoparticles were twice as sensitive. Furthermore, five clinical specimens were tested to verify the usability of the developed system. FROM THE CLINICAL EDITOR: In this study, magnetic manganese ferrite nanoparticles were used to improve the performance of a novel immunoassay for the rapid and efficient detection of influenza infections.
has issue date	2013-12-10(xsd:dateTime)
bibo:doi	10.1016/j.nano.2013.11.009
bibo:pmid	24333595
has license	no-cc
sha1sum (hex)	0c41ec48ace1522ef6efb0deca6a6f2864213bb5
schema:url	https://doi.org/10.1016/j.nano.2013.11.009
resource representing a document's title	Magnetic nanoparticle-based immunoassay for rapid detection of influenza infections by using an integrated microfluidic system
has PubMed Central identifier	PMC7106285
has PubMed identifier	24333595
schema:publication	Nanomedicine
resource representing a document's body	covid:0c41ec48ace1522ef6efb0deca6a6f2864213bb5#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0c41ec48ace1522ef6efb0deca6a6f2864213bb5 https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/0c41ec48ace1522ef6efb0deca6a6f2864213bb5
is schema:about of	named entity 'virus' named entity 'integrated' named entity 'PERFORMANCE' named entity 'MICROFLUIDIC' named entity 'SECONDS' named entity 'BASED' named entity '2 O' named entity 'INDEX' named entity 'STORAGE' named entity 'SYSTEM' named entity 'CLINICAL' named entity 'PERFORM' named entity 'PROCESS' named entity 'INFECTIONS' named entity 'VIRUS' named entity 'OPTICAL' named entity 'MANGANESE FERRITE' named entity 'STABILITY' named entity '100' named entity 'MAGNETIC' named entity 'APPROXIMATELY' named entity 'INFLUENZA' named entity 'LOW' named entity 'LONG-TERM' named entity 'BCM' named entity 'MIXING' named entity 'INTEGRATED' named entity 'AUTOMATICALLY' named entity 'SIGNALS' named entity 'CONFIRM' named entity 'ARTICLE' named entity '4.5' named entity 'USED' named entity 'SPECIMENS' named entity 'TWICE' named entity 'COMPARED' named entity 'MAGNETIC BEADS' named entity 'DETECTING' named entity 'THESE' named entity 'ORIGINAL' named entity 'TESTED' named entity 'TO REDUCE' named entity 'CHIP' named entity 'PURIFICATION' named entity 'SYNTHESIZED' named entity 'SENSITIVE' named entity 'DIAMETER' named entity 'DIAGNOSIS' named entity 'NANOPARTICLES' named entity 'THEIR' named entity 'TESTED FOR' named entity 'DYNAMIC' named entity 'DETECTION' named entity 'VERIFY' named entity 'IMMUNOASSAY' named entity 'APPLY' named entity 'DETECTION LIMIT' named entity 'HAU' named entity 'DEAD VOLUME' named entity 'HIGH' named entity 'NANOPARTICLE' named entity 'THERMAL DECOMPOSITION' named entity 'INCLUDING' covid:arg/0c41ec48ace1522ef6efb0deca6a6f2864213bb5 named entity 'verify' named entity 'infections' named entity 'perform' named entity 'influenza' named entity 'immunoassay' named entity 'usability' named entity 'optimized' named entity 'performance'

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