About: Host Src controls gallid alpha herpesvirus 1 intercellular spread in a cellular fatty acid metabolism-dependent manner

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About: Host Src controls gallid alpha herpesvirus 1 intercellular spread in a cellular fatty acid metabolism-dependent manner Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Host Src controls gallid alpha herpesvirus 1 intercellular spread in a cellular fatty acid metabolism-dependent manner
Creator	Liu, Shengwang Shao, Yuhao Wei, Ping Gao, Qi Li, Hai Chen, Zhijie Sun, Bangyao Ma, Yong Cui, Lu Liang, Yumeng Wang, Zhitao Wu, Hanguang
source	Elsevier; Medline; PMC
abstract	Abstract Viral spread is considered a promising target for antiviral therapeutics, but the associated mechanisms remain unclear for gallid alpha herpesvirus 1 (ILTV). We previously identified proto-oncogene tyrosine-protein kinase Src (Src) as a crucial host determinant of ILTV infection. The present study revealed accelerated spread of ILTV upon Src inhibition. This phenomenon was independent of either viral replication or the proliferation of infected cells and could not be compromised by neutralizing antibody. Neither extracellular vesicles nor the direct cytosol-to-cytosol connections between adjacent cells contributed to the enhanced spread of ILTV upon Src inhibition. Further genome-wide transcriptional profile analyses in combination with functional validation identified fatty acid metabolism as an essential molecular event during modulation of the intercellular spread and subsequent cytopathic effect of ILTV by Src. Overall, these data suggest that Src controls the cell-to-cell spread of ILTV in a cellular fatty acid metabolism-dependent manner, which determines the virus's cytopathic effect.
has issue date	2019-11-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2019.08.011
bibo:pmid	31425969
has license	els-covid
sha1sum (hex)	0c436b9ce54364bff1bf25793dc3ef088c3b1801
schema:url	https://doi.org/10.1016/j.virol.2019.08.011
resource representing a document's title	Host Src controls gallid alpha herpesvirus 1 intercellular spread in a cellular fatty acid metabolism-dependent manner
has PubMed Central identifier	PMC7172859
has PubMed identifier	31425969
schema:publication	Virology
resource representing a document's body	covid:0c436b9ce54364bff1bf25793dc3ef088c3b1801#body_text
is schema:about of	named entity 'neutralizing antibody' named entity 'Overall' named entity 'herpesvirus' named entity 'PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC' named entity 'cytopathic' named entity 'remain' named entity 'compromised' named entity 'combination' named entity 'Src' named entity 'connections' named entity 'previously identified' named entity 'cytosol' named entity 'extracellular vesicles' named entity 'fatty acid metabolism' named entity 'cytosol' named entity 'Src' named entity 'herpesvirus' named entity 'immune responses' named entity 'RT-qPCR' named entity 'plaque formation' named entity 'Alphaherpesvirinae' named entity 'viral infection' named entity 'goat' named entity 'biological processes' named entity 'Src' named entity 'sensory neurons' named entity 'antibody' named entity 'infection' named entity 'latent infection' named entity 'siRNA' named entity 'western blotting' named entity 'multiplicity of infection' named entity 'siRNA' named entity 'Calcein' named entity 'diffusion' named entity 'China' named entity 'Src' named entity 'infection' named entity 'fetal bovine serum' named entity 'Src' named entity 'vaccines' named entity 'vaccines' named entity 'St. Louis' named entity 'host immunity' named entity 'pathological effects' named entity 'Hilden' named entity 'trigeminal ganglia' named entity 'CD36' named entity 'goat' named entity 'therapeutic strategies' named entity 'dengue' named entity 'transcription' named entity 'Western blotting' named entity 'cytopathic effect' named entity 'secondary antibody' named entity 'Src' named entity 'Src' named entity 'serum' named entity 'intracellular pathogens' named entity 'RT-qPCR' named entity 'DMEM' named entity 'conjugated' named entity 'lysed' named entity 'therapeutic agents' named entity 'Antibodies' named entity 'incubator' named entity 'infection' named entity 'virulence' named entity 'biophysical' named entity 'Windows'

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