About: Inhibition of retinoic acid-induced skin irritation in calorie-restricted mice

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About: Inhibition of retinoic acid-induced skin irritation in calorie-restricted mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of retinoic acid-induced skin irritation in calorie-restricted mice
Creator	Bhagavathula, Narasimharao Fay, Kevin Hanosh, Andrew Varani, James Aslam, Nadeem Barron, Adam Miller, Richard Muhammad, · Warner, Roscoe
Source	Medline; PMC
abstract	Mice on a calorie-restricted (CR) diet (total calories restricted to 70% of ad libitum; AL) for periods of time ranging from 3 to 18 months were examined for response to topical treatment with all-trans retinoic acid (RA). Daily application of a 0.1% solution of RA to the shaved skin of UM-HET3 mice on an AL diet produced a severe irritation that was evident by day 4, maximal at day 7–8 and still detectable at day 14. Skin irritation was characterized by redness, dryness, flaking and failure of the hair to grow at the treated site. In CR mice, the same treatment produced little detectable irritation. Animals were sacrificed at the end of the retinoid-treatment period (day 7 or day 14) and skin from these animals was examined histologically. In both AL and CR mice, a similar degree of epidermal hyperplasia was observed. Numerous inflammatory cells (mononuclear cells and granulocytes) were present in the skin of both groups. Occasional S100-positive cells (presumably Langerhans cells) were also observed in the epidermis of skin from both groups. S100-positive cells were also observed in the dermis. When skin from CR and AL mice was incubated in organ culture for 3 days (on day 7 after initiation of RA treatment), similar levels of four different pro-inflammatory cytokines were found in the conditioned medium. Soluble type I collagen levels were also similar. In contrast, the level of matrix metalloproteinase-9 was lower in the conditioned medium of skin from CR mice than in conditioned medium from skin cultures of AL mice. Taken together, these studies suggest that CR may provide a way to mitigate the irritation that normally accompanies RA treatment without compromising the beneficial effects of retinoid use. CR appears to exert a protective effect at the target tissue level rather than by a reduction in pro-inflammatory events, per se.
has issue date	2007-10-30(xsd:dateTime)
bibo:doi	10.1007/s00403-007-0797-y
bibo:pmid	17968574
has license	no-cc
sha1sum (hex)	0c70c564ac16ac5cae3c29fe153d7844f562fc49
schema:url	https://doi.org/10.1007/s00403-007-0797-y
resource representing a document's title	Inhibition of retinoic acid-induced skin irritation in calorie-restricted mice
has PubMed Central identifier	PMC5644022
has PubMed identifier	17968574
schema:publication	Arch Dermatol Res
resource representing a document's body	covid:0c70c564ac16ac5cae3c29fe153d7844f562fc49#body_text
is schema:about of	named entity 'INDUCED' named entity 'SKIN IRRITATION' named entity 'provide' named entity 'Langerhans cells' named entity 'skin' named entity 'S100' named entity '18 months' named entity 'diet' named entity 'HAIR' named entity 'EXAMINED FOR' named entity 'TOPICAL TREATMENT' named entity 'TISSUE' named entity 'CALORIES' named entity 'DAYS' named entity 'PRESENT' named entity 'OBSERVED' named entity 'WAY' named entity 'GROUPS' named entity 'HISTOLOGICALLY' named entity 'LEVELS' named entity 'TREATED' named entity 'IRRITATION' named entity 'EVENTS' named entity 'RATHER' named entity 'NUMEROUS' named entity 'APPLICATION' named entity 'SOLUTION' named entity 'EPIDERMIS' named entity 'PERIOD' named entity 'INITIATION' named entity 'EXAMINED' named entity 'CONTRAST' named entity 'BEN' named entity 'MATRIX METALLOPROTEINASE-9' named entity 'GROW' named entity 'DRYNESS' named entity 'DIET' named entity 'DEGREE' named entity 'RETINOID' named entity 'SUGGEST' named entity '0.1' named entity 'INCUBATED' named entity 'TAKEN' named entity 'S100' named entity 'MAXIMAL' named entity 'REDUCTION' named entity 'PROVIDE' named entity 'DAY' named entity 'GRANULOCYTES' named entity 'AD LIBITUM' named entity 'LEVEL' named entity 'SHAVED' named entity 'STUDIES' named entity 'TIME' named entity 'MITIGATE' named entity 'SKIN' named entity 'DAY 7' named entity 'TREATMENT' named entity 'SITE' named entity 'SOLUBLE' named entity 'LITTLE' named entity 'CONDITIONED MEDIUM' named entity 'INHIBITION' named entity '7-8' named entity 'ANIMALS' named entity 'DERMIS' named entity 'THESE' named entity 'CALORIE' named entity 'RETINOIC ACID' named entity 'MICE' named entity 'CULTURES' named entity 'REDNESS' named entity 'AT THE END'

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