About: Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam

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About: Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam
Creator	Oshitani, Hitoshi Okamoto, Michiko Ariyoshi, Koya Moriuchi, Hiroyuki Suzuki, Motoi Hashizume, Masahiro Toizumi, Michiko Yoshihara, Keisuke Yoshida, Lay-Myint Dang, Duc Le, Minh Nguyen, Hien Nguyen, Thuy Thi, Ai Carolle, Anita Pham, Enga Wadagni, Akpeedje
topic	covid:0c8f6c389e3049eea37e2ae1583aca3acc04bc61#this
source	Medline; PMC
abstract	Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37–3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01–3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1.
has issue date	2016-06-16(xsd:dateTime)
bibo:doi	10.1038/srep27856
bibo:pmid	27306333
has license	cc-by
sha1sum (hex)	0c8f6c389e3049eea37e2ae1583aca3acc04bc61
schema:url	https://doi.org/10.1038/srep27856
resource representing a document's title	Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam
has PubMed Central identifier	PMC4910061
has PubMed identifier	27306333
schema:publication	Sci Rep
resource representing a document's body	covid:0c8f6c389e3049eea37e2ae1583aca3acc04bc61#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0c8f6c389e3049eea37e2ae1583aca3acc04bc61
is schema:about of	named entity 'compared' named entity 'Vietnam' named entity 'Respiratory' named entity 'Association' named entity 'RISK OF' named entity 'CLINICAL' named entity 'ENROLLED' named entity 'WORLDWIDE' named entity 'REVEALED' named entity 'CLINICAL RELEVANCE' named entity 'SCREENING' named entity 'SEQUENCING' named entity 'PROSPECTIVE' named entity 'APPEARANCE' named entity 'ITS' named entity 'PNEUMONIA' named entity 'genotypes' named entity 'A/B' named entity 'During' named entity 'emergence' named entity 'January 2010' named entity 'prospective' named entity 'Pediatric' named entity 'Khanh Hoa' named entity 'pneumonia' named entity 'glycoprotein' named entity 'ARI' named entity 'hypervariable region' named entity 'ARI' named entity 'General Hospital' named entity 'epidemiological' named entity 'genotype' named entity 'genotype' named entity 'RSV' named entity 'RSV' named entity 'pediatric' named entity 'tandem duplication' named entity 'LRTI' named entity 'virus' named entity 'genotype' named entity 'Cyprus' named entity 'RSV' named entity 'RSV' named entity 'P-values' named entity 'two-sample t-test' named entity 'ARI' named entity 'pneumonia' named entity 'pediatric' named entity 'General Hospital' named entity 'RSV' named entity 'Relative risk' named entity 'ARI' named entity 'Cyprus' named entity 'ARI' named entity 'RSV' named entity 'nucleotide sequence' named entity 'sample size' named entity 'nucleotide' named entity 'ARI' named entity 'pediatric' named entity 'Biosystem' named entity 'phylogenetic tree' named entity 'U.S.'

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