About: Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection

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About: Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection
Creator	Miyazaki, Tadaaki Shimada, Takashi Fujikura, Daisuke Nakayama, Yosuke Fukada, Kazutake Kondoh, Masatoshi
Source	PMC
abstract	Infection with influenza A virus, one of the most common life-threatening viruses, causes the accumulation of inflammatory cells in the lung, which is directly correlated with influenza-associated morbidity and mortality. In this study, we investigated the potential of lysozyme-treated Enterococcus faecalis FK-23 (LFK) to prevent influenza in influenza virus-infected mice. C57BL/6N mice were orally administered LFK and intranasally infected with influenza virus A/Puerto Rico/8/34 (H1N1) at lethal doses. After infection with influenza A virus, the survival rate of the LFK-administered mice was significantly higher than that of saline-administered mice. Staining of lung sections with hematoxylin-eosin, and cell counts of lung and bronchoalveolar lavage fluid showed that oral administration of LFK suppressed the excessive infiltration of leukocytes into the lung after viral infection. Extravasation assay revealed that the arrest was mediated by modulation of pulmonary alveolar-capillary permeability. Expression levels of genes involved in matrix degradation, which are correlated with vascular permeability, were downregulated in LFK-administered mice. These findings suggest that stabilizing the integrity of the alveolar-capillary barrier by the administration of LFK improves survival rate. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-2-269) contains supplementary material, which is available to authorized users.
has issue date	2013-06-20(xsd:dateTime)
bibo:doi	10.1186/2193-1801-2-269
bibo:pmid	23853748
has license	cc-by
sha1sum (hex)	0ca1d165f27191547ad12066a497ee8a30540d3f
schema:url	https://doi.org/10.1186/2193-1801-2-269
resource representing a document's title	Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection
has PubMed Central identifier	PMC3698428
has PubMed identifier	23853748
schema:publication	Springerplus
resource representing a document's body	covid:0ca1d165f27191547ad12066a497ee8a30540d3f#body_text
is schema:about of	named entity 'downregulated' named entity 'orally administered' named entity 'These' named entity 'viruses' named entity 'leukocytes' named entity 'influenza A virus' named entity 'Extravasation' named entity 'Enterococcus faecalis' named entity 'infection' named entity 'lung' named entity 'permeability' named entity 'INFECTED' named entity 'INFLUENZA VIRUS' named entity 'FINDINGS' named entity 'LUNG' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'ORALLY' named entity 'CORRELATED' named entity 'ACCUMULATION' named entity 'DOSES' named entity 'INFILTRATION' named entity 'BARRIER' named entity 'INVESTIGATED' named entity 'EXCESSIVE' named entity 'SUGGEST' named entity 'ORAL ADMINISTRATION' named entity '2F8' named entity 'LFK' named entity 'survival rate' named entity 'oral administration' named entity 'mice' named entity 'potential' named entity 'survival rate' named entity 'arrest' named entity 'hematoxylin-eosin' named entity 'counts' named entity 'influenza' named entity 'mice' named entity 'infection' named entity 'H1N1' named entity 'capillary' named entity 'vascular permeability' named entity 'lung' named entity 'Enterococcus faecalis' named entity 'orally administered' named entity 'capillary permeability' named entity 'Staining' named entity 'mice' named entity 'attenuate' named entity 'capillary permeability' named entity 'Puerto Rico' named entity 'mice' named entity 'viral infection' named entity 'alveolar' named entity 'mice' named entity 'influenza virus' named entity 'influenza A virus' named entity 'inflammatory cells' named entity 'infection' named entity 'Enterococcus faecalis' named entity 'bronchoalveolar lavage fluid' named entity 'assay' named entity 'hematoxylin-eosin' named entity 'lung' named entity 'survival rate' named entity 'intranasally' named entity 'alveolar' named entity 'influenza virus' named entity 'lung' named entity 'After' named entity 'oral administration' named entity 'MODULATION' named entity 'HEMATOXYLIN' named entity 'ASSAY' named entity 'Expression levels of genes' named entity 'viruses'

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