About: Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV

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About: Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV
Creator	Ni, Bing Wang, Li Wu, Yuzhang Lv, Yanbo Ruan, Zhihua
Source	Medline; PMC
abstract	BACKGROUND: The spike (S) protein is a major structural glycoprotein of coronavirus (CoV), the causal agent of severe acute respiratory syndrome (SARS). The S protein is a potent target for SARS-specific cell-mediated immune responses. However, the mechanism CoV pathogenesis in SARS and the role of special CTLs in virus clearance are still largely uncharacterized. Here, we describe a study that leads to the identification of a novel HLA-A0201-restricted epitope from conserved regions of S protein. RESULTS: First, different SARS-CoV sequences were analyzed to predict eight candidate peptides from conserved regions of the S protein based upon HLA-A0201 binding and proteosomal cleavage. Four of eight candidate peptides were tested by HLA-A*0201 binding assays. Among the four candidate peptides, Sp8 (S(958-966), VLNDILSRL) induced specific CTLs both ex vivo in PBLs of healthy HLA-A2(+ )donors and in HLA-A2.1/K(b )transgenic mice immunized with a plasmid encoding full-length S protein. The immunized mice released IFN-γ and lysed target cells upon stimulation with Sp8 peptide-pulsed autologous dendritic cells in comparison to other candidates. CONCLUSION: These results suggest that Sp8 is a naturally processed epitope. We propose that Sp8 epitope should help in the characterization of mechanisms of virus control and immunopathology in SARS-CoV infection.
has issue date	2009-12-03(xsd:dateTime)
bibo:doi	10.1186/1471-2172-10-61
bibo:pmid	19958537
has license	cc-by
sha1sum (hex)	0ced1f946cce007aa319a0ba38aef2c4b14dab0e
schema:url	https://doi.org/10.1186/1471-2172-10-61
resource representing a document's title	Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV
has PubMed Central identifier	PMC2792222
has PubMed identifier	19958537
schema:publication	BMC Immunol
resource representing a document's body	covid:0ced1f946cce007aa319a0ba38aef2c4b14dab0e#body_text
is schema:about of	named entity 'IDENTIFICATION' named entity 'identification' named entity 'leads' named entity 'BMC Immunology' named entity 'SPIKE PROTEIN' named entity 'HLA-A' named entity 'EPITOPE' named entity 'SARS' named entity 'LEADS' named entity 'MECHANISM' named entity 'IS A' named entity 'DESCRIBE' named entity 'RESTRICTED' named entity 'IDENTIFICATION' named entity 'AGENT' named entity 'VIRUS CLEARANCE' named entity 'CORONAVIRUS' named entity 'GLYCOPROTEIN' named entity 'PATHOGENESIS' named entity 'STRUCTURAL' named entity 'STUDY' named entity 'CONSERVED' named entity 'TARGET' named entity 'LARGELY' named entity 'HLA-A' named entity 'REGIONS' named entity 'HERE' named entity 'SPIKE' named entity 'SARS-COV' named entity 'A MAJOR' named entity 'CELL' named entity 'IMMUNOLOGY' named entity 'PROTEIN ' named entity 'NOVEL' named entity 'RESTRICTED' named entity 'BMC' named entity 'S PROTEIN' named entity 'NOVEL' named entity '28S' named entity 'SPECIAL' named entity 'MEDIATED' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'IMMUNE RESPONSES' named entity 'EPITOPE' named entity 'CONSERVED' named entity 'SPECIFIC' named entity 'ROLE' named entity 'PROTEIN ' covid:arg/0ced1f946cce007aa319a0ba38aef2c4b14dab0e named entity 'protein' named entity 'special' named entity 'structural' named entity 'conserved regions' named entity 'epitope' named entity 'However' named entity 'glycoprotein' named entity 'HLA-A' named entity 'SARS' named entity 'protein' named entity 'epitope' named entity 'BMC Immunology' named entity 'epitope' named entity 'SARS-CoV' named entity 'HLA-A2' named entity 'SARS' named entity 'SARS-CoV' named entity 'HLA-A2' named entity 'MHC' named entity 'peptide' named entity 'pathogenesis' named entity 'peptides' named entity 'autologous' named entity 'Mountain View, CA' named entity 'PBS' named entity 'cDNA' named entity 'epitopes' named entity 'Thornwood, NY'

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