About: Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1

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About: Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
Creator	Roger, Michel Iscache, Anne-Laure Humphrey, Jean Mouland, Andrew Ward, Brian Zijenah, Lynn Ve Boily-Larouche, Geneviè
Source	Medline; PMC
abstract	BACKGROUND: Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node–specific ICAM-grabbing non-integrin (L-SIGN)), can interact with pathogens including HIV-1 and is expressed at the maternal-fetal interface, we hypothesized that it could influence MTCT of HIV-1. METHODS AND FINDINGS: To investigate the potential role of DC-SIGNR in MTCT of HIV-1, we carried out a genetic association study of DC-SIGNR in a well-characterized cohort of 197 HIV-infected mothers and their infants recruited in Harare, Zimbabwe. Infants harbouring two copies of DC-SIGNR H1 and/or H3 haplotypes (H1-H1, H1-H3, H3-H3) had a 3.6-fold increased risk of in utero (IU) (P = 0.013) HIV-1 infection and a 5.7-fold increased risk of intrapartum (IP) (P = 0.025) HIV-1 infection after adjusting for a number of maternal factors. The implicated H1 and H3 haplotypes share two single nucleotide polymorphisms (SNPs) in promoter region (p-198A) and intron 2 (int2-180A) that were associated with increased risk of both IU (P = 0.045 and P = 0.003, respectively) and IP (P = 0.025, for int2-180A) HIV-1 infection. The promoter variant reduced transcriptional activity in vitro. In homozygous H1 infants bearing both the p-198A and int2-180A mutations, we observed a 4-fold decrease in the level of placental DC-SIGNR transcripts, disproportionately affecting the expression of membrane-bound isoforms compared to infant noncarriers (P = 0.011). CONCLUSION: These results suggest that DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission.
has issue date	2009-10-07(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0007211
bibo:pmid	19809496
has license	cc-by
sha1sum (hex)	0d12fa6f695fdb75443b00c49514e7850ef461e5
schema:url	https://doi.org/10.1371/journal.pone.0007211
resource representing a document's title	Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
has PubMed Central identifier	PMC2752805
has PubMed identifier	19809496
schema:publication	PLoS One
resource representing a document's body	covid:0d12fa6f695fdb75443b00c49514e7850ef461e5#body_text
is schema:about of	named entity 'FUNCTIONAL' named entity 'INFLUENCE' named entity 'EXPRESSED' named entity 'NON-' named entity 'DC-SIGNR' named entity 'RELATED' named entity 'INTERFACE' named entity 'MOTHER-TO-CHILD TRANSMISSION' named entity 'FETAL' named entity 'LYMPH NODE' named entity 'HIV-1' named entity 'GENETIC' named entity 'BACKGROUND' named entity 'ICAM' named entity 'CHILDREN' named entity 'ASSOCIATED WITH' named entity 'VARIANTS' named entity 'MOTHER-TO-CHILD TRANSMISSION' named entity 'INCLUDING' named entity 'GIVEN' named entity 'HIV-1' named entity 'SPECIFIC' named entity 'HIV-1 INFECTION' named entity 'KNOWN' named entity 'PATHOGENS' named entity 'MAIN' named entity 'DENDRITIC CELL' named entity 'C-TYPE LECTIN RECEPTOR' named entity 'MATERNAL' named entity 'CAUSE' named entity 'SIGN' named entity 'INTERACT' named entity 'LIVER' named entity 'CD209L' named entity 'INTEGRIN' named entity 'WORLDWIDE' covid:arg/0d12fa6f695fdb75443b00c49514e7850ef461e5 named entity 'ICAM' named entity 'interact' named entity 'integrin' named entity 'MTCT' named entity 'pathogens' named entity 'fetal' named entity 'C-type lectin receptor' named entity 'MTCT' named entity 'dendritic cell' named entity 'HIV-1' named entity 'Genetic Variants' named entity 'Mother-to-Child Transmission' named entity 'HIV-1 infection' named entity 'qPCR' named entity 'genotype' named entity 'positive control' named entity 'clones' named entity 'exon' named entity 'DNA sequencing' named entity 'Qiagen' named entity 'placenta' named entity 'pathogens' named entity 'isoform' named entity 'homozygous' named entity 'HIV-2' named entity 'postpartum' named entity 'MTCT' named entity 'placenta' named entity 'clones' named entity 'CCR5' named entity 'mutation' named entity 'membrane-bound' named entity 'odds ratios' named entity 'Canada' named entity 'HIV-1' named entity 'HIV-1' named entity 'HIV-1' named entity 'exon'

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