About: Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers
Creator	Espinoza, Stefano Fleischer, Lisa Krautwurst, Dietmar Miller, Gregory Somaiya, Rachana
Source	PMC
abstract	Since its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell activation has become a topic of emerging interest. Here, we review the immunologically-relevant TAAR1 literature and incorporate open-source expression and cancer survival data meta-analyses. We provide strong evidence for TAAR1 expression in the immune system and cancers revealed through NCBI GEO datamining and discuss its regulation in a spectrum of immune cell types as well as in numerous cancers. We discuss connections and logical directions for further study of TAAR1 in immunological function, and its potential role as a mediator or modulator of immune dysregulation, immunological effects of psychostimulant drugs of abuse, and cancer progression.
has issue date	2018-06-26(xsd:dateTime)
bibo:doi	10.3389/fphar.2018.00683
bibo:pmid	29997511
has license	cc-by
sha1sum (hex)	0d1448dbed0b123a78907316826d116ad97cfbcf
schema:url	https://doi.org/10.3389/fphar.2018.00683
resource representing a document's title	Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers
has PubMed Central identifier	PMC6029583
has PubMed identifier	29997511
schema:publication	Front Pharmacol
resource representing a document's body	covid:0d1448dbed0b123a78907316826d116ad97cfbcf#body_text
is schema:about of	named entity 'JOURNAL ' named entity 'TAAR1' named entity 'PSYCHIATRIC' named entity 'GEO' named entity 'NCBI' named entity 'CELL TYPES' named entity 'CANCER' named entity 'EXPRESSION' named entity 'EVIDENCE FOR' named entity 'IMMUNE CELL' named entity 'FUNCTION' named entity 'ITS' named entity 'POTENTIAL' named entity 'MODULATOR' named entity 'CONNECTIONS' named entity 'FUNCTIONALITY' named entity 'CANCER PROGRESSION' named entity 'PSYCHOSTIMULANT' named entity 'PHARMACOLOGY' named entity 'REVIEW' named entity 'SECTION' named entity 'SURVIVAL DATA' named entity 'DRUGS OF ABUSE' named entity 'REVEALED' named entity 'TOPIC' named entity 'MEDIATOR' named entity 'CONDITIONS' named entity 'INTEREST' named entity 'DIRECTIONS' named entity 'NUMEROUS' named entity 'SOURCE' named entity 'FOCUS' named entity 'LITERATURE' named entity 'RELEVANT' named entity 'IMMUNOLOGICAL' named entity 'REGULATION' named entity 'PROVIDE' named entity 'REVIEW' named entity 'SPECTRUM' named entity 'DISCOVERY' named entity 'CANCERS' named entity 'DISCUSS' named entity 'IMMUNE SYSTEM' named entity 'STUDY' named entity 'IMMUNE DYSREGULATION' named entity 'STRONG' named entity 'IMMUNE CELL ACTIVATION' named entity 'TAAR1' named entity 'ROLE' named entity 'IMMUNE SYSTEM' named entity 'EFFECTS' named entity 'MAJOR' named entity 'REWARD' named entity 'RESEARCH' named entity 'EXPRESSION' named entity 'CANCERS' named entity 'DRUG-INDUCED' named entity 'META-ANALYSES' named entity 'META-ANALYSES' named entity 'OPEN' named entity 'HERE' named entity 'RECENTLY' named entity 'survival data' named entity 'open-source' named entity 'TAAR1' named entity 'immunological effects' named entity 'meta-analyses' named entity 'TAAR1' named entity 'Frontiers in Pharmacology' named entity 'Cancers' named entity 'TAAR1' named entity 'pancreas' named entity 'microglia' named entity 'TAAR1' named entity 'PKA' named entity 'monocytic' named entity 'gene expression'

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