About: Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus
Creator	Rahal, Paula Bittar, Cíntia Arni, Raghuvir Batista, Mariana Braga, S Campos, Fernandes Candido, Natalia Carneiro, Bruno Cláudia, Ana De Matos, Adum Duarte Lima, Maria Freitas Calmon, Marilia Lopes, Tairine Machado, Francielly Mariutti, Ricardo Nogueira, Maurício Prandini, Renata Rodrigues, Guilherme Souza, Marcos Tereza Queiroz De Andrade, Stephane
Source	PMC
abstract	Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.
has issue date	2019-01-11(xsd:dateTime)
bibo:doi	10.3390/v11010049
bibo:pmid	30641880
has license	cc-by
sha1sum (hex)	0d1d6d059b8f14bab7c89cdcda4cda11e38233dc
schema:url	https://doi.org/10.3390/v11010049
resource representing a document's title	Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus
has PubMed Central identifier	PMC6356660
has PubMed identifier	30641880
schema:publication	Viruses
resource representing a document's body	covid:0d1d6d059b8f14bab7c89cdcda4cda11e38233dc#body_text
is schema:about of	named entity 'compounds' named entity 'Oriental' named entity 'SOLUTION' named entity 'INTENSE' named entity 'ASSOCIATED WITH' named entity 'ISOLATED' named entity 'TREAT' named entity 'VIRUSES' named entity 'REPLICATION' named entity 'PHARMACOLOGICAL' named entity 'OBSERVED' named entity 'HEALTH CONDITIONS' named entity 'HAVE' named entity 'VIRUS PARTICLE' named entity 'ENTRY' named entity 'HYDRODYNAMIC' named entity 'APPROXIMATELY' named entity 'DIFFERENT' named entity 'RADIUS' named entity 'REPORT' named entity 'STRONG' named entity 'ZIKA VIRUS' named entity 'MEDICINAL HERBS' named entity 'NATURAL PRODUCTS' named entity 'ZIKA VIRUS' named entity 'VIRUS' named entity 'REDUCTION' named entity 'TO PREVENT' named entity 'HERE' named entity 'BERBERINE' named entity 'POSSESS' named entity 'SCATTERING DATA' named entity 'EMODIN' named entity 'EFFECT' named entity 'INFECTIVITY' named entity 'NATURAL' named entity 'REDUCE' named entity 'EFFECTIVE' named entity 'SEARCH' named entity 'TRIGGER' named entity 'ORIENTAL' named entity 'DYNAMIC LIGHT SCATTERING' named entity 'PROPERTIES' named entity '160' named entity 'USED' named entity 'DISCOVER' named entity 'EXPOSED TO' covid:arg/0d1d6d059b8f14bab7c89cdcda4cda11e38233dc named entity 'treat' named entity 'observed' named entity 'replication' named entity 'compounds' named entity 'emodin' named entity 'discover' named entity 'particle' named entity 'reduction' named entity 'conditions' named entity 'intense' named entity 'ways' named entity 'Herbs' named entity 'emodin' named entity 'health conditions'

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