About: Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis

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About: Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis
Creator	Fang, Wei-Huan Gu, Yuan-Xing Li, Xiao-Liang Qi, Bao-Zhu Zhang, Yi-Kai Zhou, Ying-Shan
Source	PMC
abstract	Porcine circovirus type 2 (PCV2) has recently been reported to elicit the unfolded protein response (UPR) via activation of the PERK/eIF2α (RNA-activated protein kinase-like endoplasmic reticulum (ER) kinase/eukaryotic initiation factor 2α) pathway. This study attempted to examine which viral protein might be involved in inducing UPR and whether this cellular event would lead to apoptosis of the cells expressing the viral protein. By transient expression, we found that both replicase (Rep) and capsid (Cap) proteins of PCV2 could induce ER stress as shown by increased phosphorylation of PERK with subsequent activation of the eIF2α-ATF4 (activating transcription factor 4)-CHOP (CCAAT/enhancer-binding protein homologous protein) axis. Cap expression, but not Rep, significantly reduced antiapoptotic B-cell lymphoma-2 (Bcl-2) and increased caspase-3 cleavage, possibly due to increased expression of CHOP. Since knockdown of PERK by RNA interference clearly reduced Cap-induced CHOP expression, caspase-3 cleavage, and apoptotic cell death possibly by partially rescuing Bcl-2 expression, we propose that there is connection between Cap-induced UPR and apoptosis via the PERK/eIF2α/ATF4/CHOP/Bcl-2 pathway. This study, together with our earlier studies, provides insight into the mechanisms underlying PCV2 pathogenesis.
has issue date	2017-04-01(xsd:dateTime)
bibo:doi	10.1631/jzus.b1600208
bibo:pmid	28378569
has license	green-oa
sha1sum (hex)	0d206e54d493ef254aa8c65d0ba986e473dab709
schema:url	https://doi.org/10.1631/jzus.b1600208
resource representing a document's title	Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis
has PubMed Central identifier	PMC5394096
has PubMed identifier	28378569
schema:publication	Journal of Zhejiang University-SCIENCE B
resource representing a document's body	covid:0d206e54d493ef254aa8c65d0ba986e473dab709#body_text
is schema:about of	named entity 'eIF2α' named entity 'CHOP' named entity 'CHOP' named entity 'pathogenesis' named entity 'protein' named entity 'UNDERLYING' named entity 'MIGHT BE' named entity 'KINASE' named entity 'PROVIDES' named entity 'DUE TO' named entity 'STUDY' named entity 'REP' named entity 'EARLIER' named entity 'ELICIT' named entity 'STUDIES' named entity 'PATHOGENESIS' named entity 'LEAD' named entity 'CONNECTION' named entity 'BCL-2' named entity 'SUBSEQUENT' named entity 'ANTIAPOPTOTIC' named entity 'INDUCING' named entity 'ACTIVATED' named entity 'RNA INTERFERENCE' named entity 'ACTIVATION OF APOPTOSIS' named entity 'LIKE' named entity 'INVOLVED' named entity 'PATHWAY' named entity 'OUR' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'SUBSEQUENT' named entity 'REPLICASE' named entity 'PROTEIN ' named entity 'FOUND' named entity 'ACTIVATION' named entity 'TO EXAMINE' named entity 'PERK' named entity 'CHOP' named entity 'BY INCREASED' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'PARTIALLY' named entity 'ATF4' named entity 'ATTEMPTED' named entity 'TRANSIENT EXPRESSION' named entity 'PROTEIN KINASE' named entity 'INDUCED' named entity 'BINDING PROTEIN' named entity 'B-CELL LYMPHOMA' named entity 'HOMOLOGOUS PROTEIN' named entity 'INITIATION FACTOR' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'CELLULAR EVENT' named entity 'APOPTOSIS' named entity 'REPORTED' named entity 'REDUCED' named entity 'CELLS' named entity 'ENDOPLASMIC RETICULUM' named entity 'TRANSCRIPTION FACTOR 4' named entity 'INSIGHT' named entity 'RECENTLY' named entity 'APOPTOTIC CELL DEATH' named entity 'EXPRESSION' named entity 'INCREASED PHOSPHORYLATION' named entity 'ER STRESS' named entity 'PROTEINS' named entity 'INCREASED EXPRESSION' named entity 'BUT' named entity 'CAP' named entity 'EIF2' named entity 'PROTEIN ' named entity 'CLEAVAGE' named entity 'CAPSID' named entity 'AXIS' named entity 'CASPASE-3' named entity 'INCREASED'

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