About: Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana

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About: Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana
Creator	Russell, M Brinkmann, P Essex, M Montano, M Navis, A Rarick, M Sebastiani, P Thior, I Wester, C
Source	Medline; PMC
abstract	Perinatal transmission of human immunodeficiency virus (HIV)-1 represents a major problem in many regions of the world, especially Southern Africa. With the exception of viral and proviral load, the role for maternal cofactors in perinatal transmission outcome is largely unknown. In this study, an assessment was made of peripheral blood mononuclear cells (PBMC) gene-expression profiles to better understand transcriptional changes associated with HIV-1 infection and perinatal transmission among young adult mothers with infants in Botswana. Peripheral blood mononuclear cells specimens were used from 25 HIV+ drug naive and 20 HIV− healthy mothers, similar in age and location, collected in 1999–2000 and 2003, and processed with the exact same methods, as previously described. Expression profiling of 22 277 microarray gene probes implicated a broad initiation of innate response gene-sets, including toll-like receptor, interferon-stimulated and antiviral RNA response pathways in association with maternal HIV-1 infection. Maternal transmission status was further associated with host genes that influence RNA processing and splicing patterns. In addition to real-time polymerase chain reaction validation of specific genes, enriched category validation of PBMC profiles was conducted using two independent data sets for either HIV-1 infection or an unrelated RNA virus, severe acute respiratory virus infection. HIV-1 pathogen-specific host profiles should prove a useful tool in infection and transmission intervention efforts worldwide. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/sj.gene.6364297) contains supplementary material, which is available to authorized users.
has issue date	2006-05-04(xsd:dateTime)
bibo:doi	10.1038/sj.gene.6364297
bibo:pmid	16691187
has license	no-cc
sha1sum (hex)	0d28bf4dd63a40ee27a56df7c573e556159cff56
schema:url	https://doi.org/10.1038/sj.gene.6364297
resource representing a document's title	Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana
has PubMed Central identifier	PMC7091840
has PubMed identifier	16691187
schema:publication	Genes Immun
resource representing a document's body	covid:0d28bf4dd63a40ee27a56df7c573e556159cff56#body_text
is schema:about of	named entity 'EXPRESSION PROFILING' named entity 'GENE-EXPRESSION' named entity 'PERINATAL TRANSMISSION' named entity 'BOTSWANA' named entity 'HIV-1 INFECTION' named entity 'profiling' named entity 'Botswana' named entity 'HIV-1 infection' named entity 'antiretroviral drugs' named entity 'statistical analysis' named entity 'viral RNA' named entity 'mRNA' named entity 'MX1' named entity 'microarray analysis' named entity 'HEMATOPOIETIN' named entity 'MYD88' named entity 'APOBEC3G' named entity 'IRF7' named entity 'PBMCs' named entity 'interferon' named entity 'IRFs' named entity 'antiviral' named entity 'CXCL12' named entity 'seronegative' named entity 'HIV-1 infection' named entity 'HIV-1' named entity 'SARS' named entity 'cytokines' named entity 'MYD88' named entity 'acute infection' named entity 'infection' named entity 'RNA' named entity 'viral burden' named entity 'Affymetrix' named entity 'real-time polymerase chain reaction' named entity 'microarray analysis' named entity 'viral replication' named entity 'TLR' named entity 'microarray' named entity 'expression of genes' named entity 'HIV' named entity 'immune response' named entity 'RNA' named entity 'APOBEC3G' named entity 'mRNA' named entity 'gene-expression profiles' named entity 'seronegative' named entity 'antiviral' named entity 'Eotaxin' named entity 'MYD88' named entity 'SARS' named entity 'viral load' named entity 'sample size' named entity 'HIV-1' named entity 'gene' named entity 'HIV' named entity 'IRF7' named entity 'innate immune response' named entity 'MX1' named entity 'HIV status' named entity 'US Army' named entity 'RNA processing' named entity 'ISGF3G' named entity 'AIDS' named entity 'HIV' named entity 'IRAK3' named entity 'IMMUNE RESPONSE' named entity 'infection' named entity 'RNA editing' named entity 'viral load' named entity 'long terminal repeat' named entity 'ARGs' named entity 'Toll-like receptor'

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