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About:
No evidence of SARS-CoV-2 in semen of males recovering from COVID-19
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wasabi.inria.fr
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Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
No evidence of SARS-CoV-2 in semen of males recovering from COVID-19
Creator
Pan, Feng
Li, Philip
Zhang, Xiaoping
Li, Honggang
Patel, Darshan
Spivak, Adam
Xiong, Chengliang
Hotaling, James
Alukal, Joseph
Alukal, P
Guo, Jingtao
Song, Yarong
Xiao, Xingyuan
source
Elsevier; Medline; PMC
abstract
Abstract Objective To describe detection of SARS-CoV-2 in seminal fluid of patients recovering from COVID-19 and describe the expression profile of ACE2 and TMPRSS2 within the testicle. Design observational, cross-sectional study Setting Tertiary referral center Patients Thirty-four adult Chinese males diagnosed with COVID-19 through confirmatory quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) from pharyngeal swab samples Intervention None Main Outcome Measures Identification of SARS-CoV-2 on qRT-PCR of single ejaculated semen samples. Semen quality was not assessed. Expression patterns of ACE2 and TMPRSS2 in the human testis are explored through previously published single-cell transcriptome datasets. Results Six patients (19%) demonstrated scrotal discomfort concerning for viral orchitis around the time of COVID-19 confirmation. SARS-CoV-2 was not detected in semen after a median of 31 days (IQR: 29-36 days) from COVID-19 diagnosis. Single-cell transcriptome analysis demonstrates sparse expression of ACE2 and TMPRSS2, with almost no overlapping gene expression. Conclusions SARS-CoV-2 was not detected in the semen of patients recovering from COVID-19 one month after COVID-19 diagnosis. ACE2-mediated viral entry of SARS-CoV-2 into target host cells is unlikely to occur within the human testicle based on ACE2 and TMPRSS2 expression. The long-term effects of SARS-CoV-2 on male reproductive function remain unknown.
has issue date
2020-04-17
(
xsd:dateTime
)
bibo:doi
10.1016/j.fertnstert.2020.04.024
bibo:pmid
32482249
has license
els-covid
sha1sum (hex)
0d32ef4cf9de814b91863b82011724356136aeb1
schema:url
https://doi.org/10.1016/j.fertnstert.2020.04.024
resource representing a document's title
No evidence of SARS-CoV-2 in semen of males recovering from COVID-19
has PubMed Central identifier
PMC7164916
has PubMed identifier
32482249
schema:publication
Fertil Steril
resource representing a document's body
covid:0d32ef4cf9de814b91863b82011724356136aeb1#body_text
is
schema:about
of
named entity 'Running'
named entity 'semen'
named entity 'Journal'
named entity 'COVID-19'
named entity 'expression'
named entity 'SARS-CoV-2'
named entity 'mediated'
named entity 'COVID'
named entity 'COVID'
named entity 'semen'
named entity 'COVID'
named entity 'gene expression'
named entity 't-SNE'
named entity 'orchitis'
named entity 'semen analyses'
named entity 'SARS-CoV-2'
named entity 'scrotal'
named entity 'semen'
named entity 'TMPRSS2'
named entity 'human immunodeficiency virus'
named entity 'Expression patterns'
named entity 'selection bias'
named entity 'viruses'
named entity 'SARS-CoV-2'
named entity 'RNA'
named entity 'SARS-CoV-2'
named entity 'cough'
named entity 'informed consent'
named entity 'SARS-CoV-2'
named entity 'co-expression'
named entity 'germ cells'
named entity 'TMPRSS2'
named entity 'immunobiology'
named entity 'semen'
named entity 'COVID-19'
named entity 'semen sample'
named entity 'molecular virology'
named entity 'Leydig'
named entity 'ACE2'
named entity 'semen'
named entity 'ACE2'
named entity 'testicle'
named entity 'transcriptome'
named entity 'seminal fluid'
named entity 'semen samples'
named entity 'reproductive function'
named entity 'orchitis'
named entity 'Shanghai'
named entity 'TMPRSS2'
named entity 'COVID-19'
named entity 'disease symptoms'
named entity 'long-term'
named entity 'viruses'
named entity 'immune response'
named entity 'single-cell'
named entity 'host response'
named entity 'clinical symptoms'
named entity 'fertility'
named entity 'viral entry'
named entity 'testis'
named entity 'germ cells'
named entity 'scrotal'
named entity 'scRNA-seq'
named entity 'reproductive function'
named entity 'cross-sectional study'
named entity 'Guangzhou'
named entity 'sample size'
named entity 'ejaculated'
named entity 'type II alveolar cells'
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