About: Lactic acid bacteria — promising vaccine vectors: possibilities, limitations, doubts

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lactic acid bacteria — promising vaccine vectors: possibilities, limitations, doubts
Creator	Chmielewska-Jeznach, M Szatraj, K Szczepankowska, A
Source	Medline; PMC
abstract	Gram‐positive, nonpathogenic lactic acid bacteria (LAB) are considered to be promising candidates for the development of novel, safe production and delivery systems of heterologous proteins. Recombinant LAB strains were shown to elicit specific systemic and mucosal immune responses against selected antigens. For this reason, this group of bacteria is considered as a potential replacement of classical, often pathogenic, attenuated microbial carriers. Mucosal administration of recombinant LAB, especially via the best explored and universal oral route, offers many advantages in comparison to systemic inoculation, and is attractive from the immunological and practical point of view. Research aimed at designing efficient, mucosally applied vaccines in combination with improved immunization efficiency, monitoring of in vivo antigen production, determination of optimal dose for vaccination, strain selection and characterization is a priority in modern vaccinology. This paper summarizes and organizes the available knowledge on the application of LAB as live oral vaccine vectors. It constitutes a valuable source of general information for researchers interested in mucosal vaccine development and constructing LAB strains with vaccine potential.
has issue date	2017-04-04(xsd:dateTime)
bibo:doi	10.1111/jam.13446
bibo:pmid	28295939
has license	no-cc
sha1sum (hex)	0d4a35d668a5b651ed34f13cc02525e6aee26634
schema:url	https://doi.org/10.1111/jam.13446
resource representing a document's title	Lactic acid bacteria — promising vaccine vectors: possibilities, limitations, doubts
has PubMed Central identifier	PMC7166332
has PubMed identifier	28295939
schema:publication	J Appl Microbiol
resource representing a document's body	covid:0d4a35d668a5b651ed34f13cc02525e6aee26634#body_text
is schema:about of	named entity 'Research' named entity 'advantages' named entity 'inoculation' named entity 'immunization' named entity 'production' named entity 'LAB' named entity 'Gram-positive' named entity 'Mucosal' named entity 'strains' named entity 'vectors' named entity 'vaccine' named entity 'bacteria' named entity 'Recombinant' named entity 'carriers' named entity 'proteins' named entity 'inoculation' named entity 'oral route' named entity 'vaccines' named entity 'bacteria' named entity 'Recombinant' named entity 'Gram-positive' named entity 'LAB' named entity 'vaccine' named entity 'substrate' named entity 'transgene' named entity 'polypeptide' named entity 'lactobacilli' named entity 'Th1' named entity 'genetic modifications' named entity 'cytokines' named entity 'protein content' named entity 'significant impact' named entity 'vaccination' named entity 'gp120' named entity 'purine' named entity 'vaccine' named entity 'IgG' named entity 'class II' named entity 'LcrV' named entity 'autoimmune encephalitis' named entity 'LAB' named entity 'lactobacilli' named entity 'neutralizing antibodies' named entity 'immunogenic' named entity 'kDa' named entity 'mucous membrane' named entity 'immunoglobulin' named entity 'animal model' named entity 'Streptococcus sanguis' named entity 'bacterial cells' named entity 'cadmium' named entity 'antigen' named entity 'adhesive' named entity 'L. lactis' named entity 'pseudorabies virus' named entity 'vector' named entity 'metabolic' named entity 'myelin' named entity 'Immunization' named entity 'intestine' named entity 'coronavirus' named entity 'IgA' named entity 'antigen' named entity 'genetic expression' named entity 'oropharyngeal' named entity 'auxotrophy' named entity 'GRAS' named entity 'antigens' named entity 'LAB' named entity 'vaccination' named entity 'inflammatory immune response' named entity 'IgA' named entity 'vector' named entity 'Fiat' named entity 'mice' named entity 'immune response' named entity 'gut-associated lymphoid tissue' named entity 'heterologous gene expression' named entity 'Antigen'

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