About: ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs

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About: ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
Creator	Miller, Mark Moses, Melanie Byrum, Janie Cannon, Judy Hamilton, Samantha Matthew Fricke, G Mrass, Paulus Rao Oruganti, Sreenivasa Tafoya, Justyna Yang, Lihua
Source	PMC
abstract	Effector T cell migration through tissues can enable control of infection or mediate inflammatory damage. Nevertheless, the molecular mechanisms that regulate migration of effector T cells within the interstitial space of inflamed lungs are incompletely understood. Here, we show T cell migration in a mouse model of acute lung injury with two-photon imaging of intact lung tissue. Computational analysis indicates that T cells migrate with an intermittent mode, switching between confined and almost straight migration, guided by lung-associated vasculature. Rho-associated protein kinase (ROCK) is required for both high-speed migration and straight motion. By contrast, inhibition of Gα(i) signaling with pertussis toxin affects speed but not the intermittent migration of lung-infiltrating T cells. Computational modeling shows that an intermittent migration pattern balances both search area and the duration of contacts between T cells and target cells. These data identify that ROCK-dependent intermittent T cell migration regulates tissue-sampling during acute lung injury.
has issue date	2017-10-18(xsd:dateTime)
bibo:doi	10.1038/s41467-017-01032-2
bibo:pmid	29044117
has license	cc-by
sha1sum (hex)	0d6fcb1f3cd8bc1be76ee1c74fd4aebc392e1a24
schema:url	https://doi.org/10.1038/s41467-017-01032-2
resource representing a document's title	ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
has PubMed Central identifier	PMC5647329
has PubMed identifier	29044117
schema:publication	Nat Commun
resource representing a document's body	covid:0d6fcb1f3cd8bc1be76ee1c74fd4aebc392e1a24#body_text
is schema:about of	covid:arg/0d6fcb1f3cd8bc1be76ee1c74fd4aebc392e1a24 named entity 'lungs' named entity 'acute lung injury' named entity 'target cells' named entity 'ROCK' named entity 'two-photon imaging' named entity 'cell migration' named entity 'effector T cells' named entity 'lung tissue' named entity 'molecular mechanisms' named entity 'lungs' named entity 'P-values' named entity 'time-lapse' named entity 'Z-scores' named entity 'acute lung injury' named entity '37°C' named entity 'inflammatory diseases' named entity 'dashed' named entity 'acute lung injury' named entity 'Autocorrelation' named entity 'motility' named entity 'Z-score' named entity 'isoflurane' named entity 'Z-score' named entity 'effector' named entity 'acute lung injury' named entity 'two-photon microscopy' named entity 'lungs' named entity 'anti-CD3 antibody' named entity 'cell migration' named entity 'molecular pathways' named entity 'cell movement' named entity 'CD8 +' named entity 'Bio-Rad' named entity 'CD3' named entity 'CDF' named entity 'actin' named entity 'Cell Signaling Technology' named entity 'mice' named entity 'peptide' named entity 'antibodies' named entity 'CD8 +' named entity 'antibody' named entity 'Bio-Rad' named entity 'anesthesia' named entity 'Two-photon imaging' named entity 'antibody' named entity 'Naive T cells' named entity 'CXCL12' named entity 'cell migration' named entity 'Levy walk' named entity 'effector T cells' named entity 'GFP' named entity 'test strategy' named entity 'ketamine' named entity 'GFP' named entity 'mice' named entity 'active ROCK' named entity 'euthanasia' named entity 'immunology' named entity 'pancreas' named entity 'CD8 +' named entity 'Fourier analysis' named entity 'dichroic mirror' named entity 'PTX' named entity 'tissue damage' named entity 'vector' named entity 'Lungs' named entity 'acute lung injury' named entity 'mice' named entity 'LPS' named entity 'positive correlation'

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