About: Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen
Creator	Bassi, Massimiliano De Giacomo, Tiziano Mancini, Massimiliano Pernazza, Angelina Rocca, Carlo Rullo, Emma Giulia D'amati, &
Source	Medline; PMC
abstract	Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering of macrophages, prominent and diffuse neutrophilic margination within septal vessels, and interstitial inflammatory infiltrates, mainly represented by CD8+ T lymphocytes. These features are similar to those previously described in SARS-CoV-2 infection. Subtle histologic changes suggestive pulmonary involvement by Covid-19 may be accidentally encountered in routine pathology practice, especially when extensive sampling is performed for histology. These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1007/s00428-020-02829-1
bibo:pmid	32356025
has license	no-cc
sha1sum (hex)	0e69fb26d7b81562d068355d00f13b1858981f2d
schema:url	https://doi.org/10.1007/s00428-020-02829-1
resource representing a document's title	Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen
has PubMed Central identifier	PMC7192563
has PubMed identifier	32356025
schema:publication	Virchows Arch
resource representing a document's body	covid:0e69fb26d7b81562d068355d00f13b1858981f2d#body_text
is schema:about of	named entity 'Here' named entity 'pneumocyte' named entity 'observed' named entity 'pharyngeal' named entity 'pathology' named entity 'lung' named entity 'pulmonary' named entity 'SARS-CoV-2' named entity 'INTERSTITIAL' named entity 'ALVEOLAR' named entity 'MAY BE' named entity 'RESECTED' named entity 'PCR' named entity 'FEATURES' named entity 'VESSELS' named entity 'DESCRIBED' named entity 'PHARYNGEAL SWAB' named entity 'SUGGESTIVE' named entity 'clustering' named entity 'septal' named entity 'SARS-CoV-2' named entity 'infection' named entity 'encountered' named entity 'diffuse' named entity 'time' named entity 'suggestive' named entity 'describe' named entity 'CD8+ T lymphocytes' named entity 'infection' named entity 'surgical specimen' named entity 'infection' named entity 'histologic' named entity 'lung cancer' named entity 'edema' named entity 'SARS-CoV-2' named entity 'respiratory droplets' named entity 'infection' named entity 'interstitium' named entity 'global pandemic' named entity 'SARS-CoV-2' named entity 'arterioles' named entity 'fatigue' named entity 'complete remission' named entity 'histologic' named entity 'asymptomatic patients' named entity 'reactive hyperplasia' named entity 'high-resolution CT scan' named entity 'Italy' named entity 'pneumocyte' named entity 'neutrophilic' named entity 'infection' named entity 'informed consent' named entity 'comorbidities' named entity 'meropenem' named entity 'darunavir' named entity 'macrophages' named entity 'dry cough' named entity 'diffuse alveolar damage' named entity 'lobectomy' named entity 'SARS-CoV-2' named entity 'respiratory symptoms' named entity 'histological' named entity 'infection' named entity 'clinical outcome' named entity 'diffuse alveolar damage' named entity 'histology' named entity 'subpleural' named entity 'oxygen saturation' named entity 'interstitial fibrosis' named entity 'SARS' named entity 'evolution' named entity 'virus' named entity 'lymphocytes' named entity 'antibiotics' named entity 'PCR test'

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