About: MERS-CoV spillover at the camel-human interface

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	MERS-CoV spillover at the camel-human interface
Creator	Rambaut, Andrew Dudas, Gytis Bedford, Trevor Carvalho, Luiz, Max
source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data have not been utilised to their full potential. Here, we use existing MERS-CoV sequence data to explore its phylodynamics in two of its known major hosts, humans and camels. We employ structured coalescent models to show that long-term MERS-CoV evolution occurs exclusively in camels, whereas humans act as a transient, and ultimately terminal host. By analysing the distribution of human outbreak cluster sizes and zoonotic introduction times, we show that human outbreaks in the Arabian peninsula are driven by seasonally varying zoonotic transfer of viruses from camels. Without heretofore unseen evolution of host tropism, MERS-CoV is unlikely to become endemic in humans.
has issue date	2018-01-16(xsd:dateTime)
bibo:doi	10.7554/elife.31257
bibo:pmid	29336306
has license	cc-by
sha1sum (hex)	0e8f07d17aaa0e83209868716d79a4527952c0ba
schema:url	https://doi.org/10.7554/elife.31257
resource representing a document's title	MERS-CoV spillover at the camel-human interface
has PubMed Central identifier	PMC5777824
has PubMed identifier	29336306
schema:publication	eLife
resource representing a document's body	covid:0e8f07d17aaa0e83209868716d79a4527952c0ba#body_text
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