About: Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

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About: Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors
Creator	Sokolowska, Milena
Source	Medline; PMC
abstract	BACKGROUND: Morbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide and novel clinical presentations of COVID‐19 are often reported. The range of human cells and tissues targeted by SARS‐CoV‐2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS‐CoV‐2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID‐19. METHODS: We performed RNA sequencing and explored available RNA‐Seq databases to study gene expression and co‐expression of ACE2, CD147 (BSG), CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4(+) and CD8(+) T cells, B cells and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID‐19 risk factor status. RESULTS: ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA and PPIB), CD26 (DPP4) and related molecules were expressed in both, epithelium and in immune cells. We also observed a distinct age‐related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL or blood. Additionally, CD147‐related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of ACE2‐ and CD147‐related genes in the lesional skin of patients with atopic dermatitis. CONCLUSIONS: Our data suggest different receptor repertoire potentially involved in the SARS‐CoV‐2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related with age, gender, obesity and smoking, as well as with the disease status might contribute to COVID‐19 morbidity and severity patterns.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1111/all.14429
bibo:pmid	32496587
has license	no-cc
sha1sum (hex)	0ef794460797f82cf30e8f8cfd83fb34f0673122
schema:url	https://doi.org/10.1111/all.14429
resource representing a document's title	Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors
has PubMed Central identifier	PMC7300910
has PubMed identifier	32496587
schema:publication	Allergy
resource representing a document's body	covid:0ef794460797f82cf30e8f8cfd83fb34f0673122#body_text
is schema:about of	named entity 'potential' named entity 'targeted' named entity 'caused' named entity 'receptors' named entity 'SARS-CoV-2' named entity 'expression' named entity 'factors' named entity 'comorbidities' named entity 'tissues' named entity 'asthma' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'CD26' named entity 'hypertension' named entity 'obesity' named entity 'PBMCs' named entity 'immune cells' named entity 'SLC2A1' named entity 'gene expression' named entity 'receptor' named entity 'NFATC1' named entity 'virus' named entity 'CD44' named entity 'biopsies' named entity 'ITGA6' named entity 'extracellular' named entity 'supramolecular complex' named entity 'obese' named entity 'COPD' named entity 'TMPRSS2' named entity 'S100A9' named entity 'cell types' named entity 'BSG' named entity 'amino acid transporter' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'S100A9' named entity 'SARS-CoV-2' named entity 'cytokine storm' named entity 'integrins' named entity 'monocytes' named entity 'BSG' named entity 'measles' named entity 'interact' named entity 'SARS-CoV-2' named entity 'COPD' named entity 'biopsy' named entity 'MCT4' named entity 'obese' named entity 'COVID-19' named entity 'asthma' named entity 'SARS-CoV-2' named entity 'CD147' named entity 'SLC16A7' named entity 'lung' named entity 'ACE2' named entity 'CD147' named entity 'morbidity' named entity 'plasmablasts' named entity 'CD26' named entity 'NFATC1' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'transmembrane' named entity 'SLC16A3' named entity 'BSG' named entity 'metabolism' named entity 'pDCs' named entity 'NFAT5' named entity 'cellular membranes' named entity 'NME1' named entity 'Obesity' named entity 'ACE2' named entity 'CD147' named entity 'CD26' named entity 'CD147' named entity 'epithelial tissues' named entity 'effector' named entity 'ACE2' named entity 'CD147' named entity 'SARS-CoV'

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