About: Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells

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About: Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells
Creator	Palangi, Freshteh Emara, Mohamed Samuel, Samson Triggle, Chris Thompson, I
topic	covid:0f06fc59914545bf3fdd7ae0b2cd8fe2a4208ace#this
Source	PMC
abstract	Stress Granules (SGs) are dynamic ribonucleoprotein aggregates, which have been observed in cells subjected to environmental stresses, such as oxidative stress and heat shock (HS). Although pluripotent stem cells (PSCs) are highly sensitive to oxidative stress, the role of SGs in regulating PSC self-renewal and differentiation has not been fully elucidated. Here we found that sodium arsenite (SA) and HS, but not hydrogen peroxide (H(2)O(2)), induce SG formation in human induced (hi) PSCs. Particularly, we found that these granules contain the well-known SG proteins (G3BP, TIAR, eIF4E, eIF4A, eIF3B, eIF4G, and PABP), were found in juxtaposition to processing bodies (PBs), and were disassembled after the removal of the stress. Moreover, we showed that SA and HS, but not H(2)O(2), promote eIF2α phosphorylation in hiPSCs forming SGs. Analysis of pluripotent protein expression showed that HS significantly reduced all tested markers (OCT4, SOX2, NANOG, KLF4, L1TD1, and LIN28A), while SA selectively reduced the expression levels of NANOG and L1TD1. Finally, in addition to LIN28A and L1TD1, we identified DPPA5 (pluripotent protein marker) as a novel component of SGs. Collectively, these results provide new insights into the molecular cues of hiPSCs responses to environmental insults.
has issue date	2017-07-26(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0182059
bibo:pmid	28746394
has license	cc-by
sha1sum (hex)	0f06fc59914545bf3fdd7ae0b2cd8fe2a4208ace
schema:url	https://doi.org/10.1371/journal.pone.0182059
resource representing a document's title	Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells
has PubMed Central identifier	PMC5528897
has PubMed identifier	28746394
schema:publication	PLoS One
resource representing a document's body	covid:0f06fc59914545bf3fdd7ae0b2cd8fe2a4208ace#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0f06fc59914545bf3fdd7ae0b2cd8fe2a4208ace
is schema:about of	named entity 'eIF4A' named entity 'identified' named entity 'molecular' named entity 'provide' named entity 'Effects' named entity 'induced pluripotent stem cells' named entity 'INDUCED PLURIPOTENT STEM CELLS' named entity 'HAVE' named entity 'DYNAMIC' named entity 'INDUCE' named entity 'GRANULES' named entity 'TESTED' named entity 'SENSITIVE TO OXIDATIVE STRESS' named entity 'OXIDATIVE STRESS' named entity 'RIBONUCLEOPROTEIN' named entity 'CELLS' named entity 'INSIGHTS' named entity 'LIN28A' named entity 'EIF4E' named entity '2 O' named entity 'ROLE' named entity 'COMPONENT' named entity 'DPPA5' named entity 'KNOWN' named entity 'DISASSEMBLED' named entity 'FORMATION' named entity 'HIGHLY SENSITIVE' named entity 'EIF3B' named entity 'AGGREGATES' named entity 'SODIUM ARSENITE' named entity 'SGS' named entity 'KLF4' named entity 'PLURIPOTENT' named entity 'BODIES' named entity 'ADDITION' named entity 'FOUND' named entity 'EIF4A' named entity 'THESE' named entity 'HUMAN' named entity 'FORMING' named entity 'PROMOTE' named entity 'EIF2' named entity 'INDUCED' named entity 'PHOSPHORYLATION' named entity 'MOLECULAR' named entity 'PROCESSING' named entity 'CUES' named entity 'PROTEIN MARKER' named entity 'NANOG' named entity 'OBSERVED' named entity 'PROVIDE' named entity 'JUXTAPOSITION' named entity 'OXIDATIVE' named entity 'FORMATION' named entity 'EFFECTS' named entity 'DIFFERENTIATION' named entity 'PABP' named entity 'EXPRESSION' named entity 'HUMAN' named entity 'SOX2' named entity 'PSC' named entity 'REMOVAL' named entity 'PROTEINS' named entity 'NOVEL' named entity 'MARKERS' named entity 'ENVIRONMENTAL' named entity 'EIF4G' named entity 'SELF-RENEWAL' named entity 'L1TD1' named entity 'PLURIPOTENT STEM CELLS' named entity 'H 2' named entity 'FULLY' named entity 'PSCS' named entity '28H' named entity 'STRESS GRANULE'

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