About: Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes

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About: Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes
Creator	Villalaín, José De Almeida, Rodrigo Guillé N, Jaime Prieto, Manuel
Source	Medline; PMC
abstract	The severe acute respiratory syndrome coronavirus (SARS-CoV) envelope spike (S) glycoprotein is responsible for the fusion between the membranes of the virus and the target cell. In the case of the S2 domain of protein S, it has been found a highly hydrophobic and interfacial domain flanked by the heptad repeat 1 and 2 regions; significantly, different peptides pertaining to this domain have shown a significant leakage effect and an important plaque formation inhibition, which, similarly to HIV-1 gp41, support the role of this region in the fusion process. Therefore, we have carried out a study of the binding and interaction with model membranes of a peptide corresponding to segment 1073–1095 of the SARS-CoV S glycoprotein, peptide SARS(L) in the presence of different membrane model systems, as well as the structural changes taking place in both the lipid and the peptide induced by the binding of the peptide to the membrane. Our results show that SARS(L) strongly partitions into phospholipid membranes and organizes differently in lipid environments, displaying membrane activity modulated by the lipid composition of the membrane. These data would support its role in SARS-CoV mediated membrane fusion and suggest that the region where this peptide resides could be involved in the merging of the viral and target cell membranes.
has issue date	2009-07-09(xsd:dateTime)
bibo:doi	10.1080/09687680902926203
bibo:pmid	19412834
has license	no-cc
sha1sum (hex)	0f3c683776f024554e851a59d9383a546007024f
schema:url	https://doi.org/10.1080/09687680902926203
resource representing a document's title	Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes
has PubMed Central identifier	PMC7113911
has PubMed identifier	19412834
schema:publication	Mol Membr Biol
resource representing a document's body	covid:0f3c683776f024554e851a59d9383a546007024f#body_text
is schema:about of	named entity 'peptide' named entity 'cell membranes' named entity 'lipid' named entity 'presence' named entity 'mediated' named entity 'membranes' named entity 'virus' named entity 'MODEL' named entity 'MERGING' named entity 'TAKING' named entity 'SYSTEMS' named entity 'PROTEIN S' named entity 'ENVIRONMENTS' named entity 'SPIKE' named entity 'GP41' named entity 'REGION' named entity 'CARRIED' named entity 'HIGHLY' named entity 'SUPPORT' named entity 'STRUCTURAL' named entity 'INDUCED' named entity 'TARGET CELL' covid:arg/0f3c683776f024554e851a59d9383a546007024f named entity 'DOMAIN' named entity 'VIRAL AND' named entity 'SARS' named entity 'THESE' named entity 'LIPID COMPOSITION' named entity 'PRESENCE OF' named entity 'LOOP' named entity 'INTERACTION' named entity 'PROTEIN ' named entity 'SARS-COV' named entity 'PEPTIDE' named entity 'MEMBRANES' named entity 'VIRUS PROTEIN' named entity 'DIFFERENT' named entity 'HAVE' named entity 'SUGGEST' named entity 'PEPTIDES' named entity 'FOUND' named entity 'MEMBRANE MODEL' named entity 'GLYCOPROTEIN' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'IMPORTANT' named entity 'MODULATED' named entity 'RESPONSIBLE' named entity 'PLAQUE' named entity 'DATA' named entity 'RESULTS' named entity 'ENVELOPE' named entity 'MEMBRANE' named entity 'FLANKED' named entity 'OUR' named entity 'MEMBRANES' named entity 'CASE' named entity 'FORMATION' named entity 'HYDROPHOBIC' named entity 'WHERE' named entity 'PHOSPHOLIPID' named entity 'ROLE' named entity 'COULD BE' named entity 'LIPID' named entity 'HIV-1' named entity 'LEAKAGE' named entity '28S' named entity 'REGIONS' named entity 'MODEL' named entity 'FUSION' named entity 'STUDY' named entity 'EFFECT' named entity 'MEMBRANE FUSION' named entity 'INTERACTION' named entity 'MEMBRANE ACTIVITY' named entity 'CHANGES' named entity 'PLACE' named entity 'PROCESS' named entity 'SARS-COV'

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