About: Genome Stability of Pandemic Influenza A (H1N1) 2009 Based on Analysis of Hemagglutinin and Neuraminidase Genes

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About: Genome Stability of Pandemic Influenza A (H1N1) 2009 Based on Analysis of Hemagglutinin and Neuraminidase Genes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genome Stability of Pandemic Influenza A (H1N1) 2009 Based on Analysis of Hemagglutinin and Neuraminidase Genes
Creator	Espínola, Emilio
source	PMC
abstract	Influenza A virus (H1N1), which arose in 2009, constituted the fourth pandemic after the cases of 1918, 1957, and 1968. This new variant was formed by a triple reassortment, with genomic segments from swine, avian, and human influenza origins. The objective of this study was to analyze sequences of hemagglutinin (n=2038) and neuraminidase (n=1273) genes, in order to assess the extent of diversity among circulating 2009-2010 strains, estimate if these genes evolved through positive, negative, or neutral selection models of evolution during the pandemic phase, and analyze the worldwide percentage of detection of important amino acid mutations that could enhance the viral performance, such as transmissibility or resistance to drugs. A continuous surveillance by public health authorities will be critical to monitor the appearance of new influenza variants, especially in animal reservoirs such as swine and birds, in order to prevent the potential animal-human transmission of viruses with pandemic potential.
has issue date	2012-04-26(xsd:dateTime)
bibo:doi	10.2174/1874357901206010059
bibo:pmid	22582106
has license	cc-by-nc
sha1sum (hex)	0f6091029a2cc8ddd6a5c6ee18de7478b73daab2
schema:url	https://doi.org/10.2174/1874357901206010059
resource representing a document's title	Genome Stability of Pandemic Influenza A (H1N1) 2009 Based on Analysis of Hemagglutinin and Neuraminidase Genes
has PubMed Central identifier	PMC3349948
has PubMed identifier	22582106
schema:publication	Open Virol J
resource representing a document's body	covid:0f6091029a2cc8ddd6a5c6ee18de7478b73daab2#body_text
is schema:about of	named entity 'PANDEMIC' named entity 'PUBLIC HEALTH' named entity 'STUDY' named entity 'HUMAN INFLUENZA' named entity 'EVOLUTION' named entity 'AVIAN' named entity 'TO PREVENT' named entity 'CASES' named entity 'THESE' named entity 'ESTIMATE' named entity 'DIVERSITY' named entity 'NEUTRAL' named entity 'PERCENTAGE' named entity '1957' named entity 'CRITICAL' named entity 'TRIPLE' named entity 'VIRAL' named entity 'ASSESS' named entity 'worldwide' named entity 'public health' named entity 'estimate' named entity 'mutations' named entity 'swine' named entity 'extent' named entity 'neuraminidase' named entity 'pandemic' named entity 'Analysis' named entity 'NEW' named entity 'VIRUSES' named entity 'EVOLVED' named entity 'APPEARANCE' named entity 'IMPORTANT' named entity 'SEGMENTS' named entity 'ANIMAL' named entity 'NEURAMINIDASE' named entity 'STABILITY' named entity 'BASED' named entity 'ANALYSIS' named entity 'INFLUENZA A' named entity 'NEURAMINIDASE' named entity 'GENOMIC' named entity '1918' named entity 'AUTHORITIES' named entity 'RESERVOIRS' named entity 'NEGATIVE' named entity 'FOURTH' named entity 'ORDER' named entity 'ORIGINS' named entity 'ENHANCE' named entity 'WORLDWIDE' named entity 'TRANSMISSION' named entity 'OBJECTIVE' named entity 'EXTENT OF' named entity 'PERFORMANCE' named entity 'PANDEMIC' named entity 'SURVEILLANCE' named entity 'DRUGS' named entity 'HEMAGGLUTININ' named entity 'GENES' named entity 'GENOME' named entity 'POSITIVE' named entity 'SELECTION' named entity 'BIRDS' named entity 'INFLUENZA A VIRUS' named entity 'STRAINS' named entity 'DETECTION' named entity 'AMINO ACID' named entity 'POTENTIAL' named entity 'PHASE' named entity 'VARIANT' named entity 'GENES' named entity 'RESISTANCE TO' named entity 'SWINE' named entity 'CIRCULATING' named entity 'INFLUENZA' named entity 'SEQUENCES' named entity 'HEMAGGLUTININ' named entity 'HUMAN' named entity 'MUTATIONS' named entity 'MONITOR' named entity 'MODELS'

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