About: A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus

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About: A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus
Creator	Liu, Ping Guo, Xiaoquan Hu, Guoliang Li, Guyue Shi, Yan Wu, Qingpeng Xu, Puzhi Yang, Yitian Zhou, Changming
Source	Medline; PMC
abstract	Chicken gout resulting from nephropathogenic infectious bronchitis virus (NIBV) has become a serious kidney disease problem in chicken worldwide with alterations of the metabolic phenotypes in multiple metabolic pathways. To investigate the mechanisms in chicken responding to NIBV infection, we examined the global transcriptomic and metabolomic profiles of the chicken’s kidney using RNA-seq and GC–TOF/MS, respectively. Furthermore, we analyzed the alterations in cecal microorganism composition in chickens using 16S rRNA-seq. Integrated analysis of these three phenotypic datasets further managed to create correlations between the altered kidney transcriptomes and metabolome, and between kidney metabolome and gut microbiome. We found that 2868 genes and 160 metabolites were deferentially expressed or accumulated in the kidney during NIBV infection processes. These genes and metabolites were linked to NIBV-infection related processes, including immune response, signal transduction, peroxisome, purine, and amino acid metabolism. In addition, the comprehensive correlations between the kidney metabolome and cecal microbial community showed contributions of gut microbiota in the progression of NIBV-infection. Taken together, our research comprehensively describes the host responses during NIBV infection and provides new clues for further dissection of specific gene functions, metabolite affections, and the role of gut microbiota during chicken gout.
has issue date	2019-11-16(xsd:dateTime)
bibo:doi	10.3390/v11111070
bibo:pmid	31744152
has license	cc-by
sha1sum (hex)	0f93e8fef9ce127337fa00f8b16607d39c6415e8
schema:url	https://doi.org/10.3390/v11111070
resource representing a document's title	A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus
has PubMed Central identifier	PMC6893681
has PubMed identifier	31744152
schema:publication	Viruses
resource representing a document's body	covid:0f93e8fef9ce127337fa00f8b16607d39c6415e8#body_text
is schema:about of	named entity 'METABOLIC PATHWAYS' named entity 'ANALYSIS' named entity 'MICROORGANISM' named entity 'CAUSES' named entity 'GLOBAL' named entity 'PROGRESSION' named entity 'METABOLITES' named entity 'SIGNAL TRANSDUCTION' named entity 'GUT MICROBIOME' named entity 'USING' named entity 'RESPONSES' named entity 'WORLDWIDE' named entity 'CORRELATIONS' named entity 'ANALYZED' named entity 'EXPRESSED' named entity 'MICROBIAL COMMUNITY' named entity 'METABOLIC' named entity 'ALTERATIONS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'OUR' named entity '160' named entity 'metabolome' named entity 'chicken' named entity 'worldwide' named entity 'metabolic pathways' named entity 'gut microbiome' named entity '5B4' named entity 'CHICKENS' named entity 'TAKEN' named entity 'ASTROVIRUS' named entity 'RESEARCH' named entity 'INCLUDING' named entity 'GENE' named entity 'COMPOSITION' named entity 'DISSECTION' named entity 'METABOLITE' named entity 'MULTIPLE' named entity 'TO INVESTIGATE' named entity 'SPECIFIC' named entity 'GOUT' named entity 'GENES' named entity 'METABOLOME' named entity '16S RRNA' named entity 'INFECTION' named entity 'KIDNEY' named entity 'PROCESSES' named entity 'AFFECTIONS' named entity 'ALTERED' named entity 'PROVIDES' named entity 'MULTI' covid:arg/0f93e8fef9ce127337fa00f8b16607d39c6415e8 named entity 'CHICKEN' named entity 'OMICS' named entity 'STUDY' named entity 'INFECTED' named entity 'PROBLEM' named entity 'ACCUMULATED' named entity 'TOF' named entity 'PHENOTYPES' named entity 'VISCERAL GOUT' named entity 'THESE' named entity 'HOTSPOT' named entity 'NEW' named entity 'MECHANISMS' named entity 'FOUND' named entity 'ADDITION' named entity 'RELATED' named entity 'CECAL' named entity 'INTEGRATED' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'ROLE' named entity 'CHICKEN' named entity 'COMPREHENSIVE'

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