About: Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm
Creator	De Bellis, Antonio Fattouch, Khalil Greco, Ernesto Romiti, Silvia Vinciguerra, Mattia
Source	Medline; PMC
abstract	The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) outbreak is a public health emergency affecting different regions around the world. The lungs are often damaged due to the presence of Sars-CoV-2 binding receptor ACE2 on epithelial alveolar cells. Severity of infection varies from complete absence of symptomatology to more aggressive symptoms, characterized by sudden acute respiratory distress syndrome (ARDS), multiorgan failure, and sepsis, requiring treatment in intensive care unit (ICU). It is not still clear why the immune system is not able to efficiently suppress viral replication in a small percentage of patients. It has been documented as pathological conditions affecting the cardiovascular system, strongly associated to atherosclerotic progression, such as heart failure (HF), coronary heart disease (CHD), hypertension (HTN) and diabetes mellitus (DM), could serve as predictive factors for severity and susceptibility during Sars-CoV-2 infection. Atherosclerotic progression, as a chronic inflammation process, is characterized by immune system dysregulation leading to pro-inflammatory patterns, including interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and IL-1β. Reviewing immune system and inflammation profiles in atherosclerosis and laboratory results reported in severe COVID-19 infections, we hypothesized a pathogenetic correlation. Atherosclerosis may be an ideal pathogenetic substrate for high viral replication ability, leading to adverse outcomes, as reported in patients with cardiovascular factors. The level of atherosclerotic progression may affect a different degree of severe infection; in a vicious circle, feeding itself, Sars-CoV-2 may exacerbate atherosclerotic evolution due to excessive and aberrant plasmatic concentration of cytokines.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.3390/jcm9072095
bibo:pmid	32635302
has license	cc-by
sha1sum (hex)	0fb81d55332a82ece9fb4d25483ef30fe446d178
schema:url	https://doi.org/10.3390/jcm9072095
resource representing a document's title	Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm
has PubMed Central identifier	PMC7408959
has PubMed identifier	32635302
schema:publication	J Clin Med
resource representing a document's body	covid:0fb81d55332a82ece9fb4d25483ef30fe446d178#body_text
is schema:about of	named entity 'ideal' named entity 'adverse' named entity 'Clinical Medicine' named entity 'FEEDING' named entity 'DEGREE' named entity 'IL-1' named entity 'IDEAL' named entity 'IMMUNE SYSTEM' covid:arg/0fb81d55332a82ece9fb4d25483ef30fe446d178 named entity 'leading' named entity 'substrate' named entity 'progression' named entity 'degree' named entity 'conditions' named entity 'infection' named entity 'pathological' named entity 'atherosclerotic' named entity 'Sars-CoV-2' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'chronic inflammation' named entity 'Sars-CoV-2' named entity 'pro-inflammatory' named entity 'acute respiratory distress syndrome' named entity 'infection' named entity 'COVID' named entity 'diabetes mellitus' named entity 'heart failure' named entity 'pathogenetic' named entity 'vicious circle' named entity 'lungs' named entity 'IL-6' named entity 'viral replication' named entity 'tumor necrosis factor α' named entity 'cytokines' named entity 'ICU' named entity 'Substrate' named entity 'Cytokine Storm' named entity 'Sars' named entity 'Pathogenetic' named entity 'CHD' named entity 'clinical outcomes' named entity 'TLRs' named entity 'viremia' named entity 'cardiovascular' named entity 'pathogenetic' named entity 'incubation period' named entity 'TnI' named entity 'chronic inflammation' named entity 'infection' named entity 'drug-eluting stent' named entity 'endothelial function' named entity 'CKD' named entity 'COVID' named entity 'COVID' named entity 'pro-inflammatory' named entity 'pyroptosis' named entity 'acute phase' named entity 'proteolytic cleavage' named entity 'COVID' named entity 'pro-inflammatory' named entity 'correlation' named entity 'infectivity' named entity 'heart failure' named entity 'acute respiratory distress syndrome' named entity 'risk factors' named entity 'COVID' named entity 'IL-18' named entity 'infection' named entity 'infectivity' named entity 'cytokines' named entity 'IL-6 receptor' named entity 'immunological response' named entity 'pulmonary hypertension' named entity 'GCSF' named entity 'adaptive immunity' named entity 'NF-κβ' named entity 'virus'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software