About: Mutations in the 3c and 7b genes of feline coronavirus in spontaneously affected FIP cats

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About: Mutations in the 3c and 7b genes of feline coronavirus in spontaneously affected FIP cats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mutations in the 3c and 7b genes of feline coronavirus in spontaneously affected FIP cats
Creator	Reinacher, M Borschensky, C
Source	Elsevier; Medline; PMC
abstract	Abstract Feline infectious peritonitis (FIP) is the most frequent lethal infectious disease in cats. However, understanding of FIP pathogenesis is still incomplete. Mutations in the ORF 3c/ORF 7b genes are proposed to play a role in the occurrence of the fatal FIPV biotype. Here, we investigated 282 tissue specimens from 28 cats that succumbed to FIP. Within one cat, viral sequences from different organs were similar or identical, whereas greater discrepancies were found comparing sequences from various cats. Eleven of the cats exhibited deletions in the 3c gene, resulting in truncated amino acid sequences. The 7b gene was affected by deletions only in one cat. In three of the FIP cats, coronavirus isolates with both intact 3c genes as well as 7b genes of full length could also be detected. Thus, deletions or stop codons in the 3c sequence seem to be a frequent but not compelling feature of FIPVs.
has issue date	2014-10-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2014.07.016
bibo:pmid	25128417
has license	els-covid
sha1sum (hex)	0fd8e2c4a0d9bf2cd0631747055f315f53e5f1a8
schema:url	https://doi.org/10.1016/j.rvsc.2014.07.016
resource representing a document's title	Mutations in the 3c and 7b genes of feline coronavirus in spontaneously affected FIP cats
has PubMed Central identifier	PMC7111757
has PubMed identifier	25128417
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:0fd8e2c4a0d9bf2cd0631747055f315f53e5f1a8#body_text
is schema:about of	named entity 'sequences' named entity 'COMPARING' named entity 'INVESTIGATED' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'INCOMPLETE' named entity 'ORF' named entity 'FOUND' named entity 'UNDERSTANDING' named entity 'FEATURE' named entity 'LETHAL' named entity 'INTACT' named entity 'DETECTED' named entity 'ORGANS' named entity 'GENES' named entity 'TISSUE' named entity 'IDENTICAL' named entity 'FIPV' named entity 'FIP' named entity 'DIFFERENT' named entity 'FREQUENT' named entity 'PLAY' named entity 'SIMILAR' named entity 'SEQUENCE' named entity 'GENE' named entity 'HERE' named entity 'ISOLATES' named entity 'ROLE' covid:arg/0fd8e2c4a0d9bf2cd0631747055f315f53e5f1a8 named entity 'FELINE CORONAVIRUS' named entity 'AFFECTED' named entity 'GENES' named entity 'CATS' named entity 'STOP CODONS' named entity 'VIRAL' named entity 'BIOTYPE' named entity 'AFFECTED' named entity 'TRUNCATED' named entity 'SEQUENCES' named entity 'PROPOSED' named entity 'GREATER' named entity 'CORONAVIRUS' named entity 'PATHOGENESIS' named entity 'BUT' named entity 'VARIOUS' named entity 'DISCREPANCIES' named entity 'INFECTIOUS DISEASE' named entity 'MUTATIONS' named entity 'OCCURRENCE' named entity 'SPECIMENS' named entity 'FATAL' named entity 'CAT' named entity 'LENGTH' named entity 'FIP' named entity 'AMINO ACID SEQUENCES' named entity 'SPONTANEOUSLY' named entity 'MUTATIONS' named entity 'RESULTING IN' named entity '282' named entity 'CATS' named entity 'detected' named entity 'intact' named entity 'comparing' named entity 'Eleven' named entity 'organs' named entity 'ORF' named entity 'Mutations' named entity 'frequent' named entity 'codons' named entity 'tissue' named entity 'FIP' named entity 'amino acid sequences' named entity 'deletions' named entity 'ORF' named entity 'gene' named entity 'FIP' named entity 'mRNAs' named entity 'nested PCR' named entity 'saline' named entity 'PCR' named entity 'lymph node'

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