About: Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

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About: Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
Creator	Wang, Tao Khoshnejad, Makan Hood, Elizabeth Brenner, Jacob Kiseleva, Raisa Mitragotri, Samir Muzykantov, Vladimir Myerson, Jacob Pan, Daniel Shuvaev, Vladimir Villa, Carlos Gregory, Jason Johnston, Ian Lahann, Joerg Marcos-Contreras, Oscar Patel, Priyal Shuvaeva, Tea Armstead, William Bhamidipati, Kartik Cantu, Edward Chatterjee, Shampa Hekierski, Hugh Parhiz, Hamideh Tao, Jian-Qin Uhler, Thomas
Source	PMC
abstract	Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which NCs adsorbed onto the RBCs transfer from RBCs to the first organ downstream of the intravascular injection. RH improves delivery for a wide range of NCs and even viral vectors. For example, RH injected intravenously increases liposome uptake in the first downstream organ, lungs, by ~40-fold compared with free NCs. Intra-carotid artery injection of RH NCs delivers >10% of the injected NC dose to the brain, ~10× higher than that achieved with affinity moieties. Further, RH works in mice, pigs, and ex vivo human lungs without causing RBC or end-organ toxicities. Thus, RH is a clinically translatable platform technology poised to augment drug delivery in acute lung disease, stroke, and several other diseases.
has issue date	2018-07-11(xsd:dateTime)
bibo:doi	10.1038/s41467-018-05079-7
bibo:pmid	29992966
has license	cc-by
sha1sum (hex)	0fdbbf54d6dad837566e030e7f3bd211a6ae04f2
schema:url	https://doi.org/10.1038/s41467-018-05079-7
resource representing a document's title	Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
has PubMed Central identifier	PMC6041332
has PubMed identifier	29992966
schema:publication	Nat Commun
resource representing a document's body	covid:0fdbbf54d6dad837566e030e7f3bd211a6ae04f2#body_text
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