About: Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence

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About: Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence
Creator	Burke, Thomas Welch, Matthew Cox, Jeffery Engström, Patrik Golovkine, Guillaume Iavarone, Anthony Ingabire, Nadia Mark, Kevin Mitchell, Gabriel Rape, Michael
Source	PMC
abstract	Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step of polyubiquitin coat formation. One mechanism of evasion is to mobilize actin to the bacterial surface. Here, we show that actin mobilization is insufficient to block autophagy recognition of the pathogen Rickettsia parkeri. Instead, R. parkeri employs outer membrane protein B (OmpB) to block ubiquitylation of bacterial surface proteins, including OmpA, and subsequent recognition by autophagy receptors. OmpB is also required for the formation of a capsule-like layer. Although OmpB is dispensable for bacterial growth in endothelial cells, it is essential for R. parkeri to block autophagy in macrophages and to colonize mice because of its ability to promote autophagy evasion in immune cells. Our results indicate that OmpB acts as a protective shield to obstruct autophagy recognition, revealing a distinctive bacterial mechanism to evade antimicrobial autophagy.
has issue date	2019-10-14(xsd:dateTime)
bibo:doi	10.1038/s41564-019-0583-6
bibo:pmid	31611642
has license	no-cc
sha1sum (hex)	10218d6165dcbaa34d75f2135348cbac1ffc9ec9
schema:url	https://doi.org/10.1038/s41564-019-0583-6
resource representing a document's title	Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence
has PubMed Central identifier	PMC6988571
has PubMed identifier	31611642
schema:publication	Nat Microbiol
resource representing a document's body	covid:10218d6165dcbaa34d75f2135348cbac1ffc9ec9#body_text
is schema:about of	named entity 'Although' named entity 'OmpA' named entity 'mobilization' named entity 'autophagy' named entity 'Rickettsia' named entity 'mediated' named entity 'STEPS' named entity 'PROTECTIVE SHIELD' named entity 'FORMATION' named entity 'STEP' named entity 'MOBILIZE' named entity 'LIKE' named entity 'UBIQUITYLATION' named entity 'RECEPTORS' named entity 'acts' named entity 'immune cells' named entity 'colonize' named entity 'host' named entity 'bacteria' named entity 'autophagy' named entity 'mechanisms' named entity 'actin' named entity 'antimicrobial' named entity 'autophagy' named entity 'pathogen' named entity 'Rickettsia parkeri' named entity 'autophagy' named entity 'autophagy' named entity 'immune cells' named entity 'cytosolic' named entity 'virulence' named entity 'protein' named entity 'autophagy' named entity 'Ubiquitin' named entity 'centrifuged' named entity 'Vero cells' named entity 'PBS' named entity 'OmpA' named entity 'centrifuged' named entity 'antibody' named entity 'T75' named entity 'bacteria' named entity 'centrifugation' named entity 'centrifugation' named entity 'phagocytosis' named entity 'polyubiquitin' named entity 'bacteria' named entity 'bacterial growth' named entity 'cloned' named entity 'bacteria' named entity 'polyubiquitin' named entity 'DMEM' named entity 'mass spectrometry' named entity 'bacteria' named entity 'hrtA' named entity 'bacteria' named entity 'actin' named entity 'Vero cells' named entity 'bacteria' named entity 'epidermal growth factor' named entity 'genome sequences' named entity 'immunofluorescence microscopy' named entity 'DMEM' named entity 'polyubiquitin' named entity 'protein purification' named entity 'polyubiquitin' named entity 'DAPI' named entity 'F4/80' named entity 'primer' named entity 'sca2' named entity 'statistically significant' named entity 'transposon'

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