About: The landscape of cognitive function in recovered COVID-19 patients

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The landscape of cognitive function in recovered COVID-19 patients
Creator	Shi, Chuan Wei, Ning Hu, Shaohua Wang, Dandan Lu, Shaojia Chen, Jingkai Lyu, Hailong Zhou, Hetong
Source	Elsevier; PMC
abstract	This study aims to evaluate the impacts of COVID-19 on cognitive functions in recovered patients and its relationship with inflammatory profiles. Twenty-nine patients recovered from COVID-19 as confirmed by negative nucleic tests for two consecutive times were recruited. A total of 29 age-, gender- and education-matched healthy controls were also recruited. The cognitive functions of all subjects were evaluated by the iPad-based online neuropsychological tests, including the Trail Making Test (TMT), Sign Coding Test (SCT), Continuous Performance Test (CPT), and Digital Span Test (DST). Blood samples from all patients were collected for examining inflammatory profiles, including interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and C-reactive protein (CRP). The relationship between cognitive functions and inflammatory profiles were analyzed by Pearson correlation. In results, although no significant differences were found in TMT, SCT, and DST between the two groups, patients with COVID-19 scored lower in the correct number of the second and third parts of CPT, they also scored higher in the missing number of the third part of CPT (all P < 0.05). In patients with COVID-19, there was a trend of significant difference for lower reaction time in the first and second parts of CPT (P = 0.050, and 0.051, respectively), as well as the lower correct number of the second part of CPT (P = 0.050). Correlation analysis showed that the reaction time for the first and second parts of CPT was positively correlated with the CRP levels (r = 0.557 and 0.410, P < 0.05). In conclusion, our findings indicated that cognitive impairments exist even in patients recovered from COVID-19, and might be possibly linked to the underlying inflammatory processes.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1016/j.jpsychires.2020.06.022
has license	no-cc
sha1sum (hex)	1064784f4f199bda9e35f09d2c3a95dc8c4c0a64
schema:url	https://doi.org/10.1016/j.jpsychires.2020.06.022
resource representing a document's title	The landscape of cognitive function in recovered COVID-19 patients
has PubMed Central identifier	PMC7324344
schema:publication	J Psychiatr Res
resource representing a document's body	covid:1064784f4f199bda9e35f09d2c3a95dc8c4c0a64#body_text
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