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  • Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
Subject
  • Zoonoses
  • Mechanical ventilation
  • Viral respiratory tract infections
  • Intensive care medicine
  • Transfusion medicine
  • COVID-19
  • Complications of surgical and medical care
  • Emergency medical services
  • Emergency medicine
  • Lung disorders
  • Occupational safety and health
  • Respiratory therapy
  • Respiratory physiology
  • Respiratory system procedures
  • Transfusion reactions
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