About: Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries

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About: Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries
Creator	Goossens, H Ieven, M Claas, E Crook, D Van Loon, A Butler, C Coenen, S Coenjaerts, F Henriques-Normark, B Huygen, K Lammens, C Little, P Loens, K Vanderstraeten, A Verheij, T Zlateva, K
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: To describe the role of bacteria (including bacterial resistance), viruses (including those recently described) and mixed bacterial–viral infections in adults presenting to primary care with lower respiratory tract infection (LRTI). METHODS: In all, 3104 adults with LRTI were enrolled, of whom 141 (4.5%) had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28–35 days. We detected Streptococcus pneumoniae and Haemophilus influenzae and assessed susceptibility, atypical bacteria and viruses. RESULTS: A potential pathogen was detected in 1844 (59%) (in 350 (11%) bacterial pathogens only, in 1190 (38%) viral pathogens only, and in 304 (10%) both bacterial and viral pathogens). The most common bacterial pathogens isolated were S. pneumoniae (5.5% overall, 9.2% in CAP patients) and H. influenzae (5.4% overall, 14.2% in CAP patients). Less than 1% of S. pneumoniae were highly resistant to penicillin and 12.6% of H. influenzae were β-lactamase positive. The most common viral pathogens detected were human rhinovirus (20.1%), influenza viruses (9.9%), and human coronavirus (7.4%). Influenza virus, human parainfluenza viruses and human respiratory syncytial virus as well as human rhinovirus, human coronavirus and human metapneumovirus were detected significantly more frequently in LRTI patients than in controls. CONCLUSIONS: A bacterial pathogen is identified in approximately one in five adult patients with LRTI in primary care, and a viral pathogen in just under half, with mixed infections in one in ten. Penicillin-resistant pneumococci and β-lactamase-producing H. influenzae are uncommon. These new findings support a restrictive approach to antibiotic prescribing for LRTI and the use of first-line, narrow-spectrum agents in primary care.
has issue date	2018-02-12(xsd:dateTime)
bibo:doi	10.1016/j.cmi.2018.02.004
bibo:pmid	29447989
has license	no-cc
sha1sum (hex)	1090a40040afb791cf1d0783f4f95fa10fd2be25
schema:url	https://doi.org/10.1016/j.cmi.2018.02.004
resource representing a document's title	Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries
has PubMed Central identifier	PMC7129248
has PubMed identifier	29447989
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:1090a40040afb791cf1d0783f4f95fa10fd2be25#body_text
is schema:about of	named entity 'ADULTS' named entity 'Less' named entity 'H. influenzae' named entity 'coronavirus' named entity 'antibiotic' named entity 'S. pneumoniae' named entity 'viral pathogens' named entity 'viruses' named entity 'bacterial' named entity 'Influenza virus' named entity 'bacterial resistance' named entity 'viral pathogens' named entity 'PROSPECTIVE STUDY' named entity 'EUROPEAN' named entity 'NETWORKS' named entity 'HAEMOPHILUS INFLUENZAE' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'VIRUSES' named entity 'PATIENTS' named entity 'VIRAL PATHOGENS' named entity '12.6' named entity 'EUROPE' named entity 'RECENTLY' named entity 'THESE' named entity 'METHODS' named entity '2859' named entity 'HALF' named entity 'ADULTS' named entity 'ROLE' named entity 'HUMAN CORONAVIRUS' named entity '287' named entity 'NEW' covid:arg/1090a40040afb791cf1d0783f4f95fa10fd2be25 named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'PRESENTING' named entity 'ASSESSED' named entity 'FREQUENTLY' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'SPECTRUM' named entity 'PENICILLINRESISTANT' named entity 'BACTERIAL PATHOGEN' named entity 'RESISTANT TO PENICILLIN' named entity 'PATHOGEN' named entity 'CAP' named entity 'PRODUCING' named entity 'RESTRICTIVE' named entity 'LESS THAN' named entity 'HIGHLY' named entity 'NARROW' named entity 'UNCOMMON' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'USE OF' named entity 'POSITIVE' named entity 'BACTERIAL' named entity 'PRIMARY CARE' named entity 'PROSPECTIVE STUDY' named entity 'AETIOLOGY' named entity 'COUNTRIES' named entity 'ATYPICAL' named entity '141' named entity 'INFECT' named entity 'MATCHED' named entity 'PRIMARY CARE' named entity 'SUSCEPTIBILITY' named entity 'ADULT' named entity 'TO DESCRIBE'

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